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Benjamin J.-M. Tremblay
Researcher at University of Waterloo
Publications - 21
Citations - 458
Benjamin J.-M. Tremblay is an academic researcher from University of Waterloo. The author has contributed to research in topics: Respiratory epithelium & Interferon. The author has an hindex of 6, co-authored 18 publications receiving 177 citations.
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Journal ArticleDOI
Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue.
Jennifer A. Aguiar,Benjamin J.-M. Tremblay,Michael J. Mansfield,Owen Z. Woody,Briallen Lobb,Arinjay Banerjee,Abiram Chandiramohan,Nicholas Tiessen,Quynh T. Cao,Anna Dvorkin-Gheva,Spencer Revill,Matthew S. Miller,Christopher Carlsten,Louise Organ,Chitra Joseph,Alison E. John,Paul J. Hanson,Richard C. Austin,Bruce M. McManus,Gisli Jenkins,Karen L. Mossman,Kjetil Ask,Andrew C. Doxey,Andrew C. Doxey,Jeremy A. Hirota +24 more
TL;DR: The data suggest the presence of a mechanism dynamically regulating ACE2 expression in human lung, perhaps in periods of SARS-CoV-2 infection, and also suggest that alternative receptors for SAR's coronavirus exist to facilitate initial host cell infection.
Posted ContentDOI
Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue
Jennifer A. Aguiar,Benjamin J.-M. Tremblay,Michael J. Mansfield,Owen Z. Woody,Briallen Lobb,Arinjay Banerjee,Abiram Chandiramohan,Nicholas Tiessen,Anna Dvorkin-Gheva,Spencer Revill,Matthew S. Miller,Christopher Carlsten,Louise Organ,Chitra Joseph,Alison E. John,Paul J. Hanson,Bruce M. McManus,Gisli Jenkins,Karen L. Mossman,Kjetil Ask,Andrew C. Doxey,Andrew C. Doxey,Jeremy A. Hirota +22 more
TL;DR: The data suggest the presence of a mechanism dynamically regulating ACE2 expression in human lung, perhaps in periods of SARS-CoV-2 infection, and also suggest that alternate receptors for Sars-Cov-2 exist to facilitate initial host cell infection.
Journal ArticleDOI
Enhancing diversity analysis by repeatedly rarefying next generation sequencing data describing microbial communities
Ellen S. Cameron,Philip J. Schmidt,Benjamin J.-M. Tremblay,Monica B. Emelko,Kirsten M. Müller +4 more
TL;DR: In this article, repeated rarefying is proposed as a tool to normalize library sizes for diversity analyses, which enables proportionate representation of all observed sequences and characterization of the random variation introduced to diversity analyses by rarefy to a smaller library size shared by all samples.
Journal ArticleDOI
An assessment of genome annotation coverage across the bacterial tree of life
TL;DR: The analysis of bacterial genomes from the Genome Taxonomy Database revealed that 52 and 79 % of the average bacterial proteome could be functionally annotated based on protein and domain-based homology searches, respectively, highlighting the disparity in annotation coverage.
Journal ArticleDOI
Experimental and natural evidence of SARS-CoV-2 infection-induced activation of type I interferon responses.
Arinjay Banerjee,Nader El-Sayes,Patrick Budylowski,Rajesh Abraham Jacob,Daniel Richard,Hassaan Maan,Jennifer A. Aguiar,Wael L. Demian,Kaushal Baid,Michael R. D’Agostino,Jann Catherine Ang,Tetyana Murdza,Benjamin J.-M. Tremblay,Sam Afkhami,Mehran Karimzadeh,Aaron T. Irving,Aaron T. Irving,Lily Yip,Mario A. Ostrowski,Mario A. Ostrowski,Jeremy A. Hirota,Jeremy A. Hirota,Robert A. Kozak,Robert A. Kozak,Terence D. Capellini,Matthew S. Miller,Bo Wang,Samira Mubareka,Samira Mubareka,Allison McGeer,Allison McGeer,Andrew G. McArthur,Andrew C. Doxey,Andrew C. Doxey,Karen L. Mossman +34 more
TL;DR: In this article, the authors demonstrate that SARS-CoV-2 infection induces a type I IFN response in vitro and in moderate cases of COVID-19 severity.