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Beppino C. Giovanella
Researcher at St. Joseph Hospital
Publications - 143
Citations - 14095
Beppino C. Giovanella is an academic researcher from St. Joseph Hospital. The author has contributed to research in topics: Camptothecin & Nitrocamptothecin. The author has an hindex of 46, co-authored 143 publications receiving 13698 citations. Previous affiliations of Beppino C. Giovanella include University of Texas MD Anderson Cancer Center & University of Wisconsin-Madison.
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Journal ArticleDOI
Establishment and characterization of cell lines from human small cell and large cell carcinomas of the lung.
TL;DR: It is concluded that SCC cell lines, although individually distinct from one another, are quite homogeneous as a group in expressing a set of basic common neuro-endocrine markers, in support of the concept of a common histogenetic origin of human lung cancers.
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Correlation between response to chemotherapy of human tumors in patients and in nude mice
TL;DR: The data strongly support the validity of heterotransplants of human tumors in the nude mouse as a predictive system for testing new anticancer agents and in determining optimal treatment schedules and combinations of known drugs.
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Alkyl Esters of Camptothecin and 9-Nitrocamptothecin: Synthesis, in Vitro Pharmacokinetics, Toxicity, and Antitumor Activity
Zhisong Cao,Nick Harris,Anthony J. Kozielski,Dana Vardeman,John S. Stehlin,Beppino C. Giovanella +5 more
TL;DR: The in vitro pharmacokinetic determination of lactone levels of esters 6a and 7b showed that the biological life span of their lactone forms in human and mouse plasma significantly increased when compared with their mother compounds, camptothecin (3) and 9-nitrocampthecin (4).
Journal Article
Exceptional Lethality for Nude Mice of Cells Derived from a Primary Human Melanoma
Arnold Lockshin,Beppino C. Giovanella,de Ipolyi Pd,L. J. Williams,John Mendoza,S. O. Yim,John S. Stehlin +6 more
TL;DR: This model system may be useful for rapidly determining the effects of experimental treatment on the survival of hosts bearing human tumor cells, due to the short and reproducible survival times of nude mice inoculated i.p. with BRO cells.
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A phase I clinical and pharmacological study of oral 9-nitrocamptothecin, a novel water-insoluble topoisomerase I inhibitor.
Claire F. Verschraegen,Ethan A. Natelson,Beppino C. Giovanella,John J. Kavanagh,Andrzej P. Kudelka,Ralph S. Freedman,Creighton L. Edwards,Karen Ende,John S. Stehlin +8 more
TL;DR: 9-nitrocamptothecin may be tolerated for sustained periods of time, but has the potential for significant hematologic, gastrointestinal and urinary bladder toxicity.