B
Beppino C. Giovanella
Researcher at St. Joseph Hospital
Publications - 143
Citations - 14095
Beppino C. Giovanella is an academic researcher from St. Joseph Hospital. The author has contributed to research in topics: Camptothecin & Nitrocamptothecin. The author has an hindex of 46, co-authored 143 publications receiving 13698 citations. Previous affiliations of Beppino C. Giovanella include University of Texas MD Anderson Cancer Center & University of Wisconsin-Madison.
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Journal ArticleDOI
Preclinical evaluation of the anticancer activity and toxicity of 9-nitro-20(S)-camptothecin (Rubitecan).
Beppino C. Giovanella,John S. Stehlin,Hellmuth R. Hinz,Anthony J. Kozielski,Nick Harris,Dana Vardeman +5 more
TL;DR: It appears that rubitecan is a very promising anticancer drug with high potency against a wide spectrum of human cancers.
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Further Biologic Characteristics of a Human Carcinoembryonic Antigen-Producing Colon Carcinoma Cell Line
Benjamin Drewinko,Li-Ying Yang,Barthel Barlogie,Marvin M. Romsdahl,Marvin L. Meistrich,Mary Anne Malahy,Beppino C. Giovanella +6 more
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9-Nitrocamptothecin Liposome Aerosol Treatment of Human Cancer Subcutaneous Xenografts and Pulmonary Cancer Metastases in Mice
Vernon Knight,Eugenie S. Kleinerman,J. Clifford Waldrep,Beppino C. Giovanella,Brian E. Gilbert,Nadezhda V. Koshkina +5 more
TL;DR: L‐9NC aerosol showed a major therapeutic benefit in the treatment of subcutaneous human cancer xenografts in nude mice, suggesting that cancers at systemic sites might be responsive to this treatment.
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On the reported solubilization of carcinogenic hydrocarbons in aqueous solutions of dna.
TL;DR: It is shown clearly that under these conditions an aqueous colloidal suspension of the hydrocarbon is formed that can be sedimented completely with high-speed centrifugation or filtered completely by Millipore niters of uniform pore size and the only role the DNA plays in this phenomenon is to stabilize the colloid to some extent.
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Dependence of Anticancer Activity of Camptothecins on Maintaining Their Lactone Function
TL;DR: Camptothecins contain a lactone ring that exists in the closed form below ph 7, which coexist in a 50–50 ratio in mouse plasma and in a 90–10 ratio in human plasma due to the high affinity of human serum albumin for CPT+.