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Beppino C. Giovanella
Researcher at St. Joseph Hospital
Publications - 143
Citations - 14095
Beppino C. Giovanella is an academic researcher from St. Joseph Hospital. The author has contributed to research in topics: Camptothecin & Nitrocamptothecin. The author has an hindex of 46, co-authored 143 publications receiving 13698 citations. Previous affiliations of Beppino C. Giovanella include University of Texas MD Anderson Cancer Center & University of Wisconsin-Madison.
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Journal ArticleDOI
Crystalline Camptothecin-20(S)-O-Propionate Hydrate:A Novel Anticancer Agent with Strong Activity against 19 Human Tumor Xenografts
TL;DR: This compound has a much wider therapeutic index compared with that of the existing anticancer drugs currently in use and is highly effective against many different human tumors tested with a striking lack of toxicity.
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Sensitivity of camptothecin-resistant human leukemia cells and tumors to anticancer drugs with diverse mechanisms of action
Panayotis Pantazis,Dana Vardeman,John Mendoza,Janet Early,A. J. Kozielski,Albert DeJesus,Beppino C. Giovanella +6 more
TL;DR: Human leukemia U-937 cell clones resistant to 9-nitrocamptothecin (9NC) appear after exposure to increase 9NC-concentrations, and U- 937/CR150-generated tumors in nude mice are sensitive to etoposide.
Journal Article
"Hidden" cytotoxic antibodies that react with allogeneic cultured fetal and tumor cells contained in soluble immune complexes from normal human sera.
TL;DR: Results suggest that a heterogeneous group of natural antibodies reactive with antigens expressed on a variety of neoplastic and fetal cells circulate in normal donor sera as part of a soluble immune complex, together with a blocking anti-immunoglobulin.
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Partial characterization of human leukemia U-937 cell sublines resistant to 9-nitrocamptothecin.
Panayotis Pantazis,John Mendoza,Albert DeJesus,Eric H. Rubin,Donald Kufe,Beppino C. Giovanella +5 more
TL;DR: Human leukemia U‐937 cell sublines exhibiting various levels of resistance to 9‐nitrocamptothecin (9NC) were developed after exposure to progressively increased 9NC concentrations, indicating that alternative treatments can be successfully used to inhibit growth of 9NC‐resistant U‐ 937 cells and tumors.
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Diploid human lymphoblastoid and burkitt lymphoma cell lines: Susceptibility to murine NK cells and heterotransplantation to nude mice
TL;DR: Growth of heterotransplanted EBV‐converted cell lines in the subcutaneous space of adult nude mice may be influenced by immune effectors other than NK cells.