B
Beppino C. Giovanella
Researcher at St. Joseph Hospital
Publications - 143
Citations - 14095
Beppino C. Giovanella is an academic researcher from St. Joseph Hospital. The author has contributed to research in topics: Camptothecin & Nitrocamptothecin. The author has an hindex of 46, co-authored 143 publications receiving 13698 citations. Previous affiliations of Beppino C. Giovanella include University of Texas MD Anderson Cancer Center & University of Wisconsin-Madison.
Papers
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Journal ArticleDOI
Pharmacokinetics of camptothecins administered orally.
TL;DR: It is concluded that ratios of lactone/total drug are much higher in mice than in humans, which influence the therapeutic efficacies these drugs in the two species.
Journal ArticleDOI
Establishment and characterization of a human ebv-negative b cell line (MN 60)
Göran Roos,Alice Adams,Beppino C. Giovanella,Erik Lundgren,Kenneth Nilsson,Ingrid Nordenson,Christer Sundström +6 more
TL;DR: A permanent cell line, MN 60, was established from the peripheral blood of a patient with an acute lymphoblastic leukemia (ALL) classified morphologically as being of the L3 type and monoclonal surface Ig (mu lambda) was demonstrated whereas no cytoplasmic immunoglobulin could be demonstrated.
Journal ArticleDOI
Identification of murine endogenous xenotropic retrovirus in cultured multicellular tumour spheroids from nude-mouse-passaged nasopharyngeal carcinoma.
D. H. Crawford,B. G. Achong,N M Teich,S. Finerty,J. L. Thompson,M. A. Epstein,Beppino C. Giovanella +6 more
TL;DR: After nude‐mouse‐passage, a carcinoma of the nasopharynx was found to contain a few scattered C‐t/pe retrovirus particles which provided sufficient virus production for the identification of the retrov virus as an endogenous xenotropic murine leukaemia virus and not a human agent.
Journal ArticleDOI
The role of pH and serum albumin in the metabolic conversion of 9-nitrocamptothecin to 9-aminocamptothecin by human hematopoietic and other cells.
TL;DR: This report concludes that cultures of human leukemia cells treated with 9NC generate 9AC, and investigates whether human serum albumin (HSA) modulates conversion of 9NC to 9AC by cultured cells.
Book ChapterDOI
Hyperthermic Perfusion of Extremities for Melanoma and soft Tissue Sarcomas
John S. Stehlin,Beppino C. Giovanella,P. D. de Ipolyi,L. R. Muenz,Robert F. Anderson,A. A. Gutierrez +5 more
TL;DR: Since the work of KLOPP, CREECH, and the authors' group, perfusion has attracted wide attention as a method of treating patients with certain types of malignant neoplasms of the extermities.