Berber Piet

TL;DR: This work describes another lineage-negative CD127+CD161+ ILC population found in humans that expressed the chemoattractant receptor CRTH2 and identifies a unique type of human ILC that provides an innate source of T helper type 2 (TH2) cytokines.

TL;DR: Genetic and pharmacological experiments with mice revealed that Notch activity was required for the maintenance of CD103+ TRM cells, including Notch, and identified specialized programs underlying the residence, persistence, vigilance and tight control of human lungTRM cells.

TL;DR: In this article, a set of transcription factors was found to be active in integrin αE (CD103)+ TRM cells, including Notch, which indicated that Notch activity was required for the maintenance of CD103+TRM cells.

TL;DR: The specificity and function of CD103⁺CD8⁺ T cells in protecting human lung against viral infection is determined and this mechanism may provide a rapid and efficient response to influenza infection, without inducing cytotoxic damage to the delicate epithelial barrier.

TL;DR: The transcriptional signature of CD4+ TRM was determined, identified by the expression of CD103, retrieved from human lung resection material, and constitutively expressed high transcript levels of numerous cytotoxic mediators that was functionally reflected by a fast recall response, magnitude of cytokine production, and a high degree of polyfunctionality.