S
Sara Trifari
Researcher at Genentech
Publications - 17
Citations - 3344
Sara Trifari is an academic researcher from Genentech. The author has contributed to research in topics: T cell & Genetic enhancement. The author has an hindex of 11, co-authored 17 publications receiving 3117 citations. Previous affiliations of Sara Trifari include La Jolla Institute for Allergy and Immunology.
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Journal ArticleDOI
Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161.
Jenny Mjösberg,Sara Trifari,Sara Trifari,Natasha K Crellin,Natasha K Crellin,Charlotte P. Peters,Cornelis M. van Drunen,Berber Piet,Wytske Fokkens,Tom Cupedo,Hergen Spits +10 more
TL;DR: This work describes another lineage-negative CD127+CD161+ ILC population found in humans that expressed the chemoattractant receptor CRTH2 and identifies a unique type of human ILC that provides an innate source of T helper type 2 (TH2) cytokines.
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Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T H -17, T H 1 and T H 2 cells
Sara Trifari,Charles D. Kaplan,Elise H Tran,Elise H Tran,Natasha K Crellin,Hergen Spits,Hergen Spits +6 more
TL;DR: A previously uncharacterized IL-22-producing human helper T cell population that coexpressed the chemokine receptor CCR6 and the skin-homing receptors CCR4 and CCR10 is described, which may be important in skin homeostasis and pathology.
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Human NKp44+IL-22+ cells and LTi-like cells constitute a stable RORC+ lineage distinct from conventional natural killer cells
TL;DR: It is proposed that CD127+RORC+ cells, although they share some characteristics with cNK cells, represent a functionally and developmentally distinct lineage.
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Regulation of cytokine secretion in human CD127(+) LTi-like innate lymphoid cells by Toll-like receptor 2.
Natasha K Crellin,Sara Trifari,Charles D. Kaplan,Naoko Satoh-Takayama,Naoko Satoh-Takayama,James P. Di Santo,James P. Di Santo,Hergen Spits +7 more
TL;DR: The results indicate that human LTi-like ILC can directly sense bacterial components and unravel a previously unrecognized functional heterogeneity among this important population of innate lymphoid cells.
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Wiskott-Aldrich syndrome protein regulates lipid raft dynamics during immunological synapse formation.
Loïc Dupré,Alessandro Aiuti,Sara Trifari,Silvana Martino,Paola Saracco,Claudio Bordignon,Maria Grazia Roncarolo +6 more
TL;DR: It is demonstrated that the Wiskott-Aldrich syndrome protein (WASP) is recruited to lipid rafts immediately after TCR and CD28 triggering and is required for the movements of lipid rafting.