C
Cornelis M. van Drunen
Researcher at University of Amsterdam
Publications - 62
Citations - 4586
Cornelis M. van Drunen is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Innate lymphoid cell & Allergy. The author has an hindex of 25, co-authored 56 publications receiving 3509 citations. Previous affiliations of Cornelis M. van Drunen include Leiden University & Academic Medical Center.
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Journal ArticleDOI
Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161.
Jenny Mjösberg,Sara Trifari,Sara Trifari,Natasha K Crellin,Natasha K Crellin,Charlotte P. Peters,Cornelis M. van Drunen,Berber Piet,Wytske Fokkens,Tom Cupedo,Hergen Spits +10 more
TL;DR: This work describes another lineage-negative CD127+CD161+ ILC population found in humans that expressed the chemoattractant receptor CRTH2 and identifies a unique type of human ILC that provides an innate source of T helper type 2 (TH2) cytokines.
Journal ArticleDOI
Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers.
Peter Tomassen,Griet Vandeplas,Thibaut Van Zele,Lars-Olaf Cardell,Julia Arebro,Heidi Olze,U Förster-Ruhrmann,Marek L. Kowalski,Agnieszka Olszewska-Ziąber,Gabriele Holtappels,Natalie De Ruyck,Xiangdong Wang,Cornelis M. van Drunen,Joaquim Mullol,Peter Hellings,Valérie Hox,Elina Toskala,Glenis Scadding,Valerie J. Lund,Luo Zhang,Wytske Fokkens,Claus Bachert,Claus Bachert +22 more
TL;DR: Distinct CRS clusters with diverse inflammatory mechanisms largely correlated with phenotypes and further differentiated them and provided a more accurate description of the inflammatory mechanisms involved than phenotype information only.
Journal ArticleDOI
The Transcription Factor GATA3 Is Essential for the Function of Human Type 2 Innate Lymphoid Cells
Jenny Mjösberg,Jochem H. Bernink,Korneliusz Golebski,Julien J. Karrich,Charlotte P. Peters,Bianca Blom,Anje A. te Velde,Wytske Fokkens,Cornelis M. van Drunen,Hergen Spits +9 more
TL;DR: GATA3, potently regulated by TSLP, is identified as an essential transcription factor for the function of human ILC2s, which have the capacity to produce high amounts of type 2 cytokines in response to T SLP plus IL-33.
Journal ArticleDOI
IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs
Suzanne M. Bal,Jochem H. Bernink,Maho Nagasawa,Jelle Groot,Medya Shikhagaie,Kornel Golebski,Cornelis M. van Drunen,René Lutter,René E. Jonkers,Pleun Hombrink,Melanie Bruchard,Julien Villaudy,J. Marius Munneke,Wytske Fokkens,Jonas S. Erjefält,Hergen Spits,Xavier Romero Ros +16 more
TL;DR: It is proposed that IL-12 and IL-4 govern ILC2 functional identity and that their imbalance results in the perpetuation of type 1 or type 2 inflammation.
Journal ArticleDOI
International consensus statement on allergy and rhinology: rhinosinusitis 2021
Richard R. Orlandi,Todd T. Kingdom,Timothy L. Smith,Benjamin S. Bleier,Adam S. DeConde,Amber U Luong,David M. Poetker,Zachary M. Soler,Kevin C. Welch,Sarah K. Wise,Nithin D. Adappa,Jeremiah A. Alt,Wilma Terezinha Anselmo-Lima,Claus Bachert,Claus Bachert,Claus Bachert,Fuad M. Baroody,Pete S. Batra,Manuel Bernal-Sprekelsen,Daniel M. Beswick,Neil Bhattacharyya,Rakesh K. Chandra,Eugene H. Chang,Alexander G. Chiu,Naweed I. Chowdhury,Martin J. Citardi,Noam A. Cohen,David B. Conley,John M. DelGaudio,Martin Desrosiers,Richard G. Douglas,Jean Anderson Eloy,Wytske Fokkens,Stacey T. Gray,David A. Gudis,Daniel L. Hamilos,Joseph K. Han,Richard J. Harvey,Peter Hellings,Eric H. Holbrook,Claire Hopkins,Peter H. Hwang,Amin R. Javer,Rong San Jiang,David N. Kennedy,Robert C. Kern,Tanya M. Laidlaw,Devyani Lal,Andrew P. Lane,Heung Man Lee,Jivianne T. Lee,Joshua M. Levy,Sandra Y. Lin,Valerie J. Lund,Kevin C. McMains,Ralph Metson,Joaquim Mullol,Robert M. Naclerio,Gretchen M. Oakley,Nobuyoshi Otori,James N. Palmer,Sanjay R. Parikh,Desiderio Passali,Zara M. Patel,Anju T. Peters,Carl Philpott,Alkis J. Psaltis,Vijay R. Ramakrishnan,Murugappan Ramanathan,Hwan Jung Roh,Luke Rudmik,Raymond Sacks,Rodney J. Schlosser,Ahmad R. Sedaghat,Brent A. Senior,Raj Sindwani,Kristine A. Smith,Kornkiat Snidvongs,Michael G. Stewart,Jeffrey D. Suh,Bruce K. Tan,Justin H. Turner,Cornelis M. van Drunen,Richard Louis Voegels,De Yun Wang,Bradford A. Woodworth,Peter-John Wormald,Erin D. Wright,Carol H. Yan,Luo Zhang,Bing Zhou +90 more
TL;DR: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in the understanding and treatment of rhinologic disease.