P
Pierre M. Barker
Researcher at University of North Carolina at Chapel Hill
Publications - 92
Citations - 6449
Pierre M. Barker is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Health care & Public health. The author has an hindex of 36, co-authored 91 publications receiving 5476 citations. Previous affiliations of Pierre M. Barker include University of Liverpool.
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Journal ArticleDOI
High-quality health systems in the Sustainable Development Goals era: time for a revolution
Margaret E Kruk,Anna D. Gage,Catherine Arsenault,Keely Jordan,Hannah H. Leslie,Sanam Roder-DeWan,Olusoji Adeyi,Pierre M. Barker,Bernadette Daelmans,Svetlana V. Doubova,Mike English,Ezequiel García Elorrio,Frederico C. Guanais,Oye Gureje,Lisa R. Hirschhorn,Lixin Jiang,Edward Kelley,Ephrem T. Lemango,Jerker Liljestrand,Address Malata,Tanya Marchant,Malebona Precious Matsoso,John G. Meara,Manoj Mohanan,Youssoupha Ndiaye,Ole Frithjof Norheim,K. Srinath Reddy,Alexander K. Rowe,Joshua A. Salomon,Gagan Thapa,Nana A Y Twum-Danso,Muhammad Pate +31 more
TL;DR: High-quality health systems in the Sustainable Development Goals era: time for a revolution.
Journal ArticleDOI
Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice
Edith Hummler,Pierre M. Barker,John T. Gatzy,Friedrich Beermann,Chantal Verdumo,Andrea Schmidt,Richard C. Boucher,Bernard C. Rossier +7 more
TL;DR: It is shown that ENaC plays a critical role in the adaptation of the newborn lung to air breathing and was abolished in airway epithelia from αENaC(−/−) mice that developed respiratory distress and died within 40 h of birth from failure to clear their lungs of liquid.
Journal ArticleDOI
Pulmonary epithelial sodium-channel dysfunction and excess airway liquid in pseudohypoaldosteronism
Eitan Kerem,T. Bistritzer,Aaron Hanukoglu,T. Hofmann,Zhaoqing Zhou,William D. Bennett,E. Maclaughlin,Pierre M. Barker,M. Nash,Lynne M. Quittell,Richard C. Boucher,Michael R. Knowles +11 more
TL;DR: It is demonstrated that sodium transport has a role in regulating the volume of liquid on airway surfaces in patients with systemic pseudohypoaldosteronism, a salt-losing disorder caused by loss-of-function mutations in the genes for the epithelial sodium channel.
Journal ArticleDOI
Macrolide antibiotics for cystic fibrosis.
TL;DR: This review aimed to test the hypotheses that macrolide antibiotics, whilst not directly active against Pseudomonas aeruginosa, may have indirect actions against this bacteria and assess the optimal type, dose and duration of Macrolide therapy.
Journal ArticleDOI
Role of gammaENaC subunit in lung liquid clearance and electrolyte balance in newborn mice. Insights into perinatal adaptation and pseudohypoaldosteronism.
Pierre M. Barker,MyTrang Nguyen,John T. Gatzy,Barbara R. Grubb,Hilary Norman,Edith Hummler,Bernard C. Rossier,Richard C. Boucher,Beverly H. Koller +8 more
TL;DR: It is suggested that gammaENaC facilitates neonatal lung liquid clearance and is critical for renal Na+ and K+ transport, and that low level Na+ transport may be sufficient for perinatal lungLiquid absorption but insufficient to maintain electrolyte balance by the distal nephron.