B
Bernard Khor
Researcher at Benaroya Research Institute
Publications - 28
Citations - 2898
Bernard Khor is an academic researcher from Benaroya Research Institute. The author has contributed to research in topics: Immune system & Inflammation. The author has an hindex of 13, co-authored 25 publications receiving 2449 citations. Previous affiliations of Bernard Khor include Massachusetts Institute of Technology & Harvard University.
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Journal ArticleDOI
Genetics and pathogenesis of inflammatory bowel disease
TL;DR: Recent advances have provided substantial insight into the maintenance of mucosal immunity and the pathogenesis of inflammatory bowel disease, and the role of genetic predispositions and how they affect interactions with microbial and environmental factors is emphasized.
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ATG5 regulates plasma cell differentiation
Kara L. Conway,Petric Kuballa,Bernard Khor,Mei Zhang,Hai Ning Shi,Herbert W. Virgin,Ramnik J. Xavier +6 more
TL;DR: It is shown here that this autophagy gene is essential for plasma cell homeostasis, and a role for ATG5 in early B cell development is illustrated, illustrating its importance in late B cell activation and subsequent plasma cell differentiation.
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Laboratory tests for antithrombin deficiency.
TL;DR: The appropriate steps to take when antithrombin activity is low, in order to confirm or exclude a hereditary deficiency are described.
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The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells
Bernard Khor,John D. Gagnon,Gautam Goel,Marly I. Roche,Kara L. Conway,Khoa D. Tran,Leslie N Aldrich,Thomas B. Sundberg,Alison M. Paterson,Scott Mordecai,David Dombkowski,Melanie Schirmer,Pauline H. Tan,Atul K. Bhan,Rahul Roychoudhuri,Nicholas P. Restifo,John J. O'Shea,Benjamin D. Medoff,Alykhan F. Shamji,Stuart L. Schreiber,Arlene H. Sharpe,Stanley Y. Shaw,Ramnik J. Xavier +22 more
TL;DR: DYRK1A is identified as a physiologically relevant regulator of Treg cell differentiation and a broader role for other DYRK family members in immune homeostasis is suggested and discussed in the context of human diseases associated with dysregulated DyrK activity.
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Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells
Thomas B. Sundberg,Hwan Geun Choi,Joo Hye Song,Caitlin N. Russell,Mahmud M. Hussain,Mahmud M. Hussain,Mahmud M. Hussain,Daniel B. Graham,Bernard Khor,John D. Gagnon,Daniel J. O’Connell,Kavitha Narayan,Vlado Dančík,José Carlos Rodríguez Pérez,Hans Christian Reinecker,Nathanael S. Gray,Stuart L. Schreiber,Stuart L. Schreiber,Stuart L. Schreiber,Ramnik J. Xavier,Ramnik J. Xavier,Alykhan F. Shamji +21 more
TL;DR: A small-molecule screen that identified inhibition of salt-inducible kinases (SIKs) as a strategy to enhance IL-10 production by macrophages and dendritic cells demonstrates that SIK inhibition promotes an anti-inflammatory phenotype in activated myeloid cells marked by robust IL- 10 production.