Mahmud M. Hussain

TL;DR: The laboratory developed titanium-based catalysts for use in the synthesis of epoxy alcohols with tertiary carbinols and described the kinetic resolution (KR) of racemic allylic alcohols, a method to prepare epoxycohols containing stereogenic carbinol carbons.

TL;DR: The palladium-catalyzed allylation reaction of toluene-derived pronucleophiles activated by tricarbonylchromium is reported, and a tandem allylic substitution/demetalation procedure is described that affords the corresponding metal-free allylic replacement products.

TL;DR: A small-molecule screen that identified inhibition of salt-inducible kinases (SIKs) as a strategy to enhance IL-10 production by macrophages and dendritic cells demonstrates that SIK inhibition promotes an anti-inflammatory phenotype in activated myeloid cells marked by robust IL- 10 production.

TL;DR: 1-Alkenyl-1,1-heterobimetallics are potentially very useful in stereoselective organic synthesis but are relatively unexplored, so a practical application in the synthesis of versatile cyclopropyl alcohol boronate esters, which are valuable building blocks is introduced.

TL;DR: This work reports the identification of a tin(IV) oxochloride-derived cluster that binds an evolutionarily conserved IDR within the metazoan TFIID transcription complex and suggests a new avenue for targeting the elusive IDRs by harnessing certain features of metal-based complexes for mechanistic studies, and for the development of novel pharmaceutical interventions.