M
Mei Zhang
Researcher at Harvard University
Publications - 12
Citations - 2682
Mei Zhang is an academic researcher from Harvard University. The author has contributed to research in topics: Immune system & Heligmosomoides polygyrus. The author has an hindex of 11, co-authored 12 publications receiving 2065 citations.
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Journal ArticleDOI
A single-cell survey of the small intestinal epithelium
Adam L. Haber,Moshe Biton,Moshe Biton,Noga Rogel,Rebecca H. Herbst,Rebecca H. Herbst,Karthik Shekhar,Christopher Smillie,Grace Burgin,Toni Delorey,Toni Delorey,Michael R. Howitt,Yarden Katz,Itay Tirosh,Semir Beyaz,Danielle Dionne,Mei Zhang,Raktima Raychowdhury,Wendy S. Garrett,Wendy S. Garrett,Orit Rozenblatt-Rosen,Hai Ning Shi,Ömer H. Yilmaz,Ömer H. Yilmaz,Ramnik J. Xavier,Ramnik J. Xavier,Aviv Regev +26 more
TL;DR: This paper reported profiling of 53,193 individual epithelial cells from the small intestine and organoids of mice, which enabled the identification and characterization of previously unknown subtypes of intestinal epithelial cell and their gene signatures.
A single-cell survey of the small intestinal epithelium
Adam L. Haber,Moshe Biton,Moshe Biton,Noga Rogel,Rebecca H. Herbst,Rebecca H. Herbst,Karthik Shekhar,Christopher Smillie,Grace Burgin,Toni Delorey,Toni Delorey,Michael R. Howitt,Yarden Katz,Itay Tirosh,Semir Beyaz,Danielle Dionne,Mei Zhang,Raktima Raychowdhury,Wendy S. Garrett,Wendy S. Garrett,Orit Rozenblatt-Rosen,Hai Ning Shi,Ömer H. Yilmaz,Ömer H. Yilmaz,Ramnik J. Xavier,Ramnik J. Xavier,Aviv Regev +26 more
TL;DR: The authors reported profiling of 53,193 individual epithelial cells from the small intestine and organoids of mice, which enabled the identification and characterization of previously unknown subtypes of intestinal epithelial cell and their gene signatures.
Journal ArticleDOI
T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation.
Moshe Biton,Moshe Biton,Adam L. Haber,Noga Rogel,Grace Burgin,Semir Beyaz,Semir Beyaz,Semir Beyaz,Alexandra Schnell,Orr Ashenberg,Chien-wen Su,Christopher Smillie,Karthik Shekhar,Zuojia Chen,Chuan Wu,Jose Ordovas-Montanes,David Alvarez,Rebecca H. Herbst,Rebecca H. Herbst,Mei Zhang,Itay Tirosh,Itay Tirosh,Danielle Dionne,Lan T. Nguyen,Michael E. Xifaras,Alex K. Shalek,Ulrich H. von Andrian,Daniel B. Graham,Orit Rozenblatt-Rosen,Hai Ning Shi,Vijay K. Kuchroo,Vijay K. Kuchroo,Ömer H. Yilmaz,Ömer H. Yilmaz,Ömer H. Yilmaz,Aviv Regev,Aviv Regev,Ramnik J. Xavier +37 more
TL;DR: It is shown that MHCII+ Lgr5+ ISCs are non-conventional antigen-presenting cells in co-cultures with CD4+ T helper (Th) cells, which orchestrate tissue-wide responses to external signals.
Journal ArticleDOI
Atg16l1 is Required for Autophagy in Intestinal Epithelial Cells and Protection of Mice From Salmonella Infection
Kara L. Conway,Petric Kuballa,Joo Hye Song,Khushbu Patel,Adam B. Castoreno,Ömer H. Yilmaz,Humberto Jijon,Mei Zhang,Leslie N. Aldrich,Eduardo J. Villablanca,Joanna M. Peloquin,Gautam Goel,In-Ah Lee,Emiko Mizoguchi,Hai Ning Shi,Atul K. Bhan,Stanley Y. Shaw,Stuart L. Schreiber,Herbert W. Virgin,Alykhan F. Shamji,Thaddeus S. Stappenbeck,Hans Christian Reinecker,Ramnik J. Xavier +22 more
TL;DR: Atg16l1 regulates autophagy in intestinal epithelial cells and is required for bacterial clearance, and also is required to prevent systemic infection of mice with enteric bacteria.
Journal ArticleDOI
ATG5 regulates plasma cell differentiation
Kara L. Conway,Petric Kuballa,Bernard Khor,Mei Zhang,Hai Ning Shi,Herbert W. Virgin,Ramnik J. Xavier +6 more
TL;DR: It is shown here that this autophagy gene is essential for plasma cell homeostasis, and a role for ATG5 in early B cell development is illustrated, illustrating its importance in late B cell activation and subsequent plasma cell differentiation.