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Alison M. Paterson
Researcher at Harvard University
Publications - 19
Citations - 2137
Alison M. Paterson is an academic researcher from Harvard University. The author has contributed to research in topics: T cell & Cellular differentiation. The author has an hindex of 11, co-authored 19 publications receiving 1844 citations. Previous affiliations of Alison M. Paterson include Brigham and Women's Hospital.
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Journal ArticleDOI
The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells
Aurelie T Bauquet,Hulin Jin,Alison M. Paterson,Meike Mitsdoerffer,I-Cheng Ho,Arlene H. Sharpe,Vijay K. Kuchroo +6 more
TL;DR: The data suggest that ICOS-induced c-Maf regulates IL-21 production that in turn regulates the expansion of TH-17 and TFH cells.
Journal ArticleDOI
Role of the PD-1 Pathway in the Immune Response
TL;DR: The upregulation of PD‐L1 on nonhematopoietic cells of the allograft may actively participate in the inhibition of immune responses and provide tissue‐specific protection.
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The Coinhibitory Receptor CTLA-4 Controls B Cell Responses by Modulating T Follicular Helper, T Follicular Regulatory, and T Regulatory Cells
Peter T. Sage,Alison M. Paterson,Alison M. Paterson,Scott B. Lovitch,Arlene H. Sharpe,Arlene H. Sharpe +5 more
TL;DR: It is found that non-Tfr Treg cells could suppress B cell responses through CTLA-4 and that Treg and/or Tfr cells might downregulate B7-2 on B cells outside germinal centers as a means of suppression.
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The Programmed Death-1 Ligand 1:B7-1 Pathway Restrains Diabetogenic Effector T Cells In Vivo
Alison M. Paterson,Keturah E. Brown,Mary E. Keir,Vijay K. Vanguri,Leonardo V. Riella,Anil Chandraker,Mohamed H. Sayegh,Bruce R. Blazar,Gordon J. Freeman,Arlene H. Sharpe +9 more
TL;DR: Data demonstrate that the PD-L1:B7-1 pathway inhibits potentially pathogenic self-reactive effector CD4+ and CD8+ T cell responses in vivo, and suggest that the immunoinhibitory functions of this pathway may be particularly important during the later phases of diabetogenesis.
Journal ArticleDOI
Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity.
Alison M. Paterson,Alison M. Paterson,Scott B. Lovitch,Scott B. Lovitch,Peter T. Sage,Peter T. Sage,Vikram R. Juneja,Vikram R. Juneja,Youjin Lee,Justin D. Trombley,Justin D. Trombley,Carolina V. Arancibia-Cárcamo,Raymond A. Sobel,Alexander Y. Rudensky,Vijay K. Kuchroo,Gordon J. Freeman,Arlene H. Sharpe,Arlene H. Sharpe +17 more
TL;DR: It is demonstrated that, in contrast to CTLA-4 germline knockout mice, conditional deletion on T reg cells during adulthood confers protection from EAE and does not increase resistance to tumors.