B
Bernhard Lohkamp
Researcher at Karolinska Institutet
Publications - 28
Citations - 22962
Bernhard Lohkamp is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Active site & Thymine. The author has an hindex of 15, co-authored 26 publications receiving 18345 citations. Previous affiliations of Bernhard Lohkamp include Nanyang Technological University & University of Glasgow.
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Journal ArticleDOI
Crystal Structures of the Kinase Domain of the Sulfate-Activating Complex in Mycobacterium Tuberculosis.
Ömer Poyraz,Katharina Brunner,Bernhard Lohkamp,Hanna Axelsson,Lars Hammarström,Robert Schnell,Gunter Schneider +6 more
TL;DR: The crystal structures of CysC from M. tuberculosis are determined and show the typical APS kinase fold, and the structures provide comprehensive views of the catalytic machinery, conserved in this enzyme family.
Journal ArticleDOI
Substrate Channel Flexibility in Pseudomonas aeruginosa MurB Accommodates Two Distinct Substrates.
TL;DR: Three-dimensional structures of the ternary complex of Pseudomonas aeruginosa MurB with FAD and NADP+ are determined to help in structure-aided drug design against MurB, which is essential for cell wall biogenesis and hence bacterial survival.
Journal ArticleDOI
Crystal structure and pH-dependent allosteric regulation of human β-ureidopropionase, an enzyme involved in anticancer drug metabolism.
TL;DR: The crystal structure of the T299C variant refined to 2.08 Å resolution revealed high structural conservation between human and fruit fly βUP, and supports the hypothesis that enzyme activation by oligomer assembly involves ordering of loop regions forming the entrance to the active site at the dimer-dimer interface.
Journal ArticleDOI
CCP4 Cloud for structure determination and project management in macromolecular crystallography
Eugene Krissinel,Andrey Lebedev,Ville Uski,Charles B. Ballard,Ronan M. Keegan,Oleg Kovalevskiy,Robert A. Nicholls,Navraj S. Pannu,Pavol Skubák,John M. Berrisford,M. S. Fando,Bernhard Lohkamp,Marcin Wojdyr,Adam J. Simpkin,Jens M. H. Thomas,C. Oliver,Clemens Vonrhein,Grzegorz Chojnowski,Arnaud Baslé,Andrew Purkiss,Michail N. Isupov,Stuart McNicholas,Edward D. Lowe,José María Guerrero Triviño,Kevin Cowtan,Jon Agirre,Daniel J. Rigden,Isabel Usón,Victor S. Lamzin,Ivo Tews,Gérard Bricogne,A. Leslie,Dave Brown +32 more
TL;DR: The paper describes CCP4 Cloud, an online system for macromolecular structure determination based on the CCP4 software suite that is applicable to nanofiltration, X-ray diffraction, and high-performance liquid chromatography.
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Identification of Two Novel Mutations C79X and R235Q in the Dihydropyrimidine Dehydrogenase Gene in a Patient Presenting With Hematuria
A. B. P. Van Kuilenburg,Judith Meijer,Doreen Dobritzsch,Bernhard Lohkamp,W Ruitenbeek,Jeroen Roelofsen,Nico G.G.M. Abeling,M. Duran,C Buzing +8 more
TL;DR: A patient with hematuria was shown to have thymine-uraciluria and the crystal structure of pig DPD suggested that the R235Q mutation might interfere with the binding of FAD and the electron flow between the NADPH and the pyrimidine substrate site of DPD.