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Bert G de Boer
Researcher at Leiden University
Publications - 2
Citations - 394
Bert G de Boer is an academic researcher from Leiden University. The author has contributed to research in topics: Chitosan & Intestinal mucosa. The author has an hindex of 2, co-authored 2 publications receiving 380 citations.
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Journal ArticleDOI
Comparison of the effect of different chitosan salts and N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2)
A.F Kotzé,A.F Kotzé,H.L. Lueßen,Bas. J. de Leeuw,Bert G de Boer,J. Coos Verhoef,Hans E. Junginger +6 more
TL;DR: It is concluded from this study that the charge, charge density and the structural features of chitosans and chitOSan derivatives are important factors determining their potential use as absorption enhancers.
Journal ArticleDOI
Effect of the degree of quaternization of N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2).
A.F Kotzé,A.F Kotzé,Maya Thanou,H.L. Lueßen,Bert G de Boer,J. Coos Verhoef,Hans E. Junginger +6 more
TL;DR: The results show that TMC is able to open the tight junctions of intestinal epithelial cells to allow for paracellular transport of hydrophilic molecules and it is concluded that the charge density of TMC, as determined by the degree of quaternization, is an important factor determining its potential use as an absorption enhancer across intestinal epithelia.