H
H.L. Lueßen
Researcher at Leiden University
Publications - 13
Citations - 1893
H.L. Lueßen is an academic researcher from Leiden University. The author has contributed to research in topics: Chitosan & Paracellular transport. The author has an hindex of 10, co-authored 13 publications receiving 1838 citations.
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Journal ArticleDOI
Mucoadhesive polymers in peroral peptide drug delivery. VI. Carbomer and chitosan improve the intestinal absorption of the peptide drug buserelin in vivo.
H.L. Lueßen,Bas. J. de Leeuw,Mariska W. E. Langemeÿer,A. G. De Boer,J. Coos Verhoef,Hans E. Junginger +5 more
TL;DR: The mucoadhesive polymers carbomer 934P and chitosan hydrochloride are able to enhance the intestinal absorption of buserelin in vivo in rats, and may therefore be promising excipients in peroral delivery systems for peptide drugs.
Journal ArticleDOI
Comparison of the effect of different chitosan salts and N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2)
A.F Kotzé,A.F Kotzé,H.L. Lueßen,Bas. J. de Leeuw,Bert G de Boer,J. Coos Verhoef,Hans E. Junginger +6 more
TL;DR: It is concluded from this study that the charge, charge density and the structural features of chitosans and chitOSan derivatives are important factors determining their potential use as absorption enhancers.
Journal ArticleDOI
Effect of degree of quaternization of N-trimethyl chitosan chloride for enhanced transport of hydrophilic compounds across intestinal caco-2 cell monolayers.
Maya Thanou,A.F Kotzé,A.F Kotzé,T Scharringhausen,H.L. Lueßen,A. G. De Boer,John Verhoef,H. E. Junginger +7 more
TL;DR: High charge density is necessary for TMC to substantially improve the paracellular permeability of intestinal epithelia and it is expected that TMC40 and TMC60 will enhance the intestinal permeation of hydrophilic macromolecular drugs such as peptides and proteins.
Journal ArticleDOI
Chitosan for enhanced intestinal permeability: prospects for derivatives soluble in neutral and basic environments.
TL;DR: There is a need for chitosan derivatives with increased solubility, especially at neutral and basic pH values, for use as absorption enhancers aimed at the delivery of therapeutic compounds in the more basic environment of the large intestine and colon.
Journal ArticleDOI
Mucoadhesive polymers in peroral peptide drug delivery. IV. Polycarbophil and chitosan are potent enhancers of peptide transport across intestinal mucosae in vitro
H.L. Lueßen,C.-O. Rentel,A.F Kotzé,Claus-Michael Lehr,A. G. De Boer,J.C. Verhoef,Hans E. Junginger +6 more
TL;DR: It is concluded that the chitosans enhance the transport of DGAVP solely by increasing the paracellular permeability due to opening of intercellular junctions, which allows for sufficient concentration and thus transport of the peptide drug when polycarbophil inducedParacellular transport is less enhanced.