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Bertram L. Koelsch
Researcher at University of California, San Francisco
Publications - 13
Citations - 347
Bertram L. Koelsch is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 7, co-authored 9 publications receiving 298 citations. Previous affiliations of Bertram L. Koelsch include University of California, Berkeley.
Papers
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Journal ArticleDOI
Hyperpolarized 13C-pyruvate magnetic resonance reveals rapid lactate export in metastatic renal cell carcinomas.
Kayvan R. Keshari,Renuka Sriram,Bertram L. Koelsch,Mark Van Criekinge,David M. Wilson,John Kurhanewicz,Zhen J. Wang +6 more
TL;DR: Investigation of the dynamic metabolic flux in living RCC cells using hyperpolarized (13)C-pyruvate magnetic resonance spectroscopy combined with a bioreactor platform and interrogated the biochemical basis of the MRS data with respect to cancer aggressiveness shows that such differential cellular transporter expression and associated metabolic phenotype can be noninvasively assessed.
Journal ArticleDOI
High Resolution $^{13}$ C MRI With Hyperpolarized Urea: In Vivo $T_{2}$ Mapping and $^{15}$ N Labeling Effects
Galen D. Reed,Cornelius von Morze,Robert Bok,Bertram L. Koelsch,Mark Van Criekinge,Kenneth J. Smith,Hong Shang,Peder E. Z. Larson,John Kurhanewicz,Daniel B. Vigneron +9 more
TL;DR: The enhanced T2 of [(13)C,(15)N2] urea was utilized to generate large signal enhancement by SSFP acquisitions with flip angles approaching the fully refocused regime, with both urea isotopes giving a greater than four-fold increase in signal-to-noise ratio.
Journal ArticleDOI
Metabolic response of prostate cancer to nicotinamide phophoribosyltransferase inhibition in a hyperpolarized MR/PET compatible bioreactor.
Kayvan R. Keshari,David M. Wilson,Mark Van Criekinge,Renuka Sriram,Bertram L. Koelsch,Zhen J. Wang,Henry F. VanBrocklin,Donna M. Peehl,Thomas O'Brien,Deepak Sampath,Richard A.D. Carano,John Kurhanewicz +11 more
TL;DR: Hyperpolarized (HP) [1‐13C] pyruvate is a clinically translatable probe that allows real‐time assessment of metabolism and describes changes in flux with treatment, non‐invasive biomarkers are necessary.
Journal ArticleDOI
Imaging Renal Urea Handling in Rats at Millimeter Resolution using Hyperpolarized Magnetic Resonance Relaxometry.
Galen D. Reed,Cornelius von Morze,Alan S. Verkman,Bertram L. Koelsch,Myriam M. Chaumeil,Michael Lustig,Sabrina M. Ronen,Robert Bok,Jeff M. Sands,Peder E. Z. Larson,Zhen J. Wang,Jan Henrik Ardenkjær Larsen,John Kurhanewicz,Daniel B. Vigneron +13 more
TL;DR: In this study, in vivo T2 heterogeneity of hyperpolarized [13C,15N2]urea in rat kidney has been investigated and a T2-edited, ultralong echo time sequence was developed for sub-2 mm3 resolution 3-dimensional encoding of urea by exploiting relaxation differences in the vascular and filtrate pools.
Journal ArticleDOI
Diffusion MR of hyperpolarized 13C molecules in solution
Bertram L. Koelsch,Bertram L. Koelsch,Kayvan R. Keshari,Tom H. Peeters,Peder E. Z. Larson,Peder E. Z. Larson,David M. Wilson,John Kurhanewicz,John Kurhanewicz +8 more
TL;DR: The feasibility of using hyperpolarized (13)C diffusion-weighted MR to accurately measure real-time (seconds) molecular transport phenomena is demonstrated.