Beverly L. Davidson

TL;DR: A genome-wide phylogenetic survey of lineage-specific splicing patterns in the primate brain is carried out, via high-density exon junction array profiling of brain transcriptomes of humans, chimpanzees and rhesus macaques, to reveal widespread human-specific changes of alternative splicing in the brain and suggest an important role of splice in the evolution of neuronal gene regulation and functions.

TL;DR: Experiments in feasibility studies in the CNS with application to animal models of inherited disease, neurodegenerative diseases, and cerebrovascular disease have identified specific limitations and directed further research to improve vector design, formulation, and delivery.

TL;DR: Cationic molecules improve the efficiency of adenovirus-mediated gene transfer to blood vessels by alteration of the surface charge of adnovirus and facilitation of binding to endothelium.

TL;DR: In this paper, small interfering RNA molecules (siRNA) targeted against an allele of interest, and methods of using these siRNA molecules were presented, and the present invention was directed to small interferingRNA (siRN) targeted to small RNA molecules.

TL;DR: It is suggested that both macrophage depletion and CD40 ligand blockade inhibit immune responses to recombinant adenovirus to slow decline of transgene expression, while only CD40ligand blockade inhibits anti-Ad antibody generation sufficiently to allow redosing to the liver.