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Beverly L. Davidson
Researcher at Children's Hospital of Philadelphia
Publications - 410
Citations - 35019
Beverly L. Davidson is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Gene silencing & RNA interference. The author has an hindex of 94, co-authored 391 publications receiving 33041 citations. Previous affiliations of Beverly L. Davidson include United States Department of Veterans Affairs & University of California, Los Angeles.
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Journal ArticleDOI
A Mouse Model of Classical Late-Infantile Neuronal Ceroid Lipofuscinosis Based on Targeted Disruption of the CLN2 Gene Results in a Loss of Tripeptidyl-Peptidase I Activity and Progressive Neurodegeneration
David E. Sleat,Jennifer A. Wiseman,Mukarram El-Banna,Kwi Hye Kim,Qinwen Mao,Sandy M. Price,Shannon L. Macauley,Richard L. Sidman,Michael M. Shen,Michael M. Shen,Qi Zhao,Marco A. Passini,Beverly L. Davidson,Gregory R. Stewart,Gregory R. Stewart,Peter Lobel,Peter Lobel +16 more
TL;DR: The CLN2-targeted mouse represents an animal model that should provide clues to the normal cellular function of TPP I and the pathogenic processes that underlie neuronal death in its absence and represents a valuable model for the evaluation of different therapeutic strategies.
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Reinstating Aberrant mTORC1 Activity in Huntington’s Disease Mice Improves Disease Phenotypes
John H. Lee,Luis Tecedor,Yong Hong Chen,Alex Mas Monteys,Matthew J. Sowada,Leslie M. Thompson,Beverly L. Davidson +6 more
TL;DR: It is shown that introducing the constitutively active form of the mTORC1 regulator, Rheb, into HD mouse brain, alleviates mitochondrial dysfunction, aberrant cholesterol homeostasis, striatal atrophy, impaired dopamine signaling, and increases autophagy.
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Differential effects of glial cell line-derived neurotrophic factor (GDNF) in the striatum and substantia nigra of the aged Parkinsonian rat
Bronwen Connor,Dorothy A. Kozlowski,Timothy J Schallert,Jennifer L. Tillerson,Beverly L. Davidson,Martha C. Bohn +5 more
TL;DR: It is demonstrated that increased levels of striatal, but not nigral, GDNF biosynthesis prevents DA neuronal loss and protects DA terminals from 6-OHDA-induced damage, thereby maintaining DA function in the aged rat.
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Functional Rescue of the Sarcoglycan Complex in the BIO 14.6 Hamster Using δ-Sarcoglycan Gene Transfer
Kathleen H. Holt,Leland E. Lim,Volker Straub,David Venzke,Franck Duclos,Richard D. Anderson,Beverly L. Davidson,Kevin P. Campbell +7 more
TL;DR: The sarcoglycan complex is requisite for the maintenance of sarcolemmal integrity, and primary mutations in individual sarcogly can components can be corrected in vivo.
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Lentivirus Vectors Pseudotyped with Filoviral Envelope Glycoproteins Transduce Airway Epithelia from the Apical Surface Independently of Folate Receptor Alpha
Patrick L. Sinn,Melissa A. Hickey,Patrick D. Staber,Douglas E. Dylla,Scott A. Jeffers,Beverly L. Davidson,David Avram Sanders,Paul B. McCray +7 more
TL;DR: F folate receptor alpha-dependent and -independent entry by filovirus glycoprotein-pseudotyped FIV-based vectors in airway epithelia are demonstrated and phosphatidylinositol-specific phospholipase C treatment and FRα-blocking antibodies are demonstrated.