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Yi Xing
Researcher at Children's Hospital of Philadelphia
Publications - 140
Citations - 15520
Yi Xing is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Alternative splicing & RNA splicing. The author has an hindex of 54, co-authored 131 publications receiving 13083 citations. Previous affiliations of Yi Xing include University of Pennsylvania & Roy J. and Lucille A. Carver College of Medicine.
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Journal ArticleDOI
A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function.
John D. Cahoy,Ben Emery,Amit Kaushal,Lynette C. Foo,Jennifer L. Zamanian,Karen S. Christopherson,Yi Xing,Jane L. Lubischer,Paul A. Krieg,Sergey A. Krupenko,Wesley J. Thompson,Ben A. Barres +11 more
TL;DR: These findings call into question the concept of a “glial” cell class as the gene profiles of astrocyte and oligodendrocytes are as dissimilar to each other as they are to neurons, for better understanding of neural development, function, and disease.
Journal ArticleDOI
rMATS: Robust and flexible detection of differential alternative splicing from replicate RNA-Seq data
Shihao Shen,Juw Won Park,Zhi-xiang Lu,Lan Lin,Michael D. Henry,Ying Nian Wu,Qing Zhou,Yi Xing +7 more
TL;DR: A new statistical model and computer program, replicate MATS (rMATS), designed for detection of differential alternative splicing from replicate RNA-Seq data, which uses a hierarchical model to simultaneously account for sampling uncertainty in individual replicates and variability among replicates.
Journal ArticleDOI
m6A RNA Modification Controls Cell Fate Transition in Mammalian Embryonic Stem Cells
Pedro J. Batista,Benoit Molinie,Jinkai Wang,Kun Qu,Jiajing Zhang,Lingjie Li,Donna M. Bouley,Ernesto Lujan,Bahareh Haddad,Kaveh Daneshvar,Ava C. Carter,Ryan A. Flynn,Chan Zhou,Kok-Seong Lim,Peter C. Dedon,Marius Wernig,Alan C. Mullen,Yi Xing,Cosmas Giallourakis,Howard Y. Chang +19 more
TL;DR: Mapping the m( 6)A methylome in mouse and human embryonic stem cells reveals the evolutionary conservation and function of m(6)A, a mark of transcriptome flexibility required for stem cells to differentiate to specific lineages.
Journal ArticleDOI
The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease.
TL;DR: It is found that levels of several microRNAs (miRNAs) with upstream RE1 sites are decreased in HD patient cortices relative to healthy controls, providing evidence for a double negative feedback loop between the REST silencing complex and the miRNAs it regulates.
Journal ArticleDOI
Structure and activity of putative intronic miRNA promoters.
Alex Mas Monteys,Ryan M. Spengler,Ji Wan,Luis Tecedor,Kim A. Lennox,Yi Xing,Beverly L. Davidson +6 more
TL;DR: It is observed that approximately 35% of intronic miRNAs have upstream regulatory elements consistent with promoter function, and ChIP analysis suggests dual regulation by both intronic (Pol III) and host gene (Pol II) promoters.