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Beverly L. Davidson
Researcher at Children's Hospital of Philadelphia
Publications - 410
Citations - 35019
Beverly L. Davidson is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Gene silencing & RNA interference. The author has an hindex of 94, co-authored 391 publications receiving 33041 citations. Previous affiliations of Beverly L. Davidson include United States Department of Veterans Affairs & University of California, Los Angeles.
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Journal ArticleDOI
SUMO-2 and PIAS1 Modulate Insoluble Mutant Huntingtin Protein Accumulation
Jacqueline G. O’Rourke,Jaclyn R. Gareau,Joseph Ochaba,Wan Song,Tamás Raskó,David Reverter,John H. Lee,Alex Mas Monteys,Judit Pallos,Lisa Mee,Malini Vashishtha,Barbara L. Apostol,Thomas Peter Nicholson,Katalin Illes,Ya-Zhen Zhu,Mary Dasso,Gillian P. Bates,Marian DiFiglia,Beverly L. Davidson,Erich E. Wanker,J. Lawrence Marsh,Christopher D. Lima,Joan S. Steffan,Leslie M. Thompson +23 more
TL;DR: The accumulation of SUMO-2-modified proteins in the insoluble fraction of HD postmortem striata implicates SUMO -2 modification in the age-related pathogenic accumulation of mutant HTT and other cellular proteins that occurs during HD progression.
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Inhibition of interleukin-1-induced effects in synoviocytes transduced with the human IL-1 receptor antagonist cDNA using an adenoviral vector.
Blake J. Roessler,John Hartman,David K. Vallance,Jill M. Latta,Sonia L. Janich,Beverly L. Davidson +5 more
TL;DR: It is demonstrated that recombinant adenoviral vectors can mediate the intra-articular expression of anti-inflammatory proteins and may be a reasonable method to deliver therapeutically relevant proteins for the regional treatment of synovial inflammation.
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Molecular basis of hypoxanthine-guanine phosphoribosyltransferase deficiency in ten subjects determined by direct sequencing of amplified transcripts.
TL;DR: The PCR is used to identify previously undetermined mutations in HPRT mRNA from B lymphoblasts derived from 10 deficient individuals, which contain single point mutations, three contain deletions, and one contains a single nucleotide insertion.
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Adeno-associated virus type 4 (AAV4) targets ependyma and astrocytes in the subventricular zone and RMS
TL;DR: This work reports specific transduction of ependyma and/or astrocytes by recombinant adeno-associated virus type 4 (AAV4) viral vectors into the subventricular zone and introduces AAV4 as a new tool by which to manipulate glial cells in the RMS.
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Systemic and Central Nervous System Correction of Lysosomal Storage in Mucopolysaccharidosis Type VII Mice
TL;DR: Results indicate that prolonged enzyme expression from transgenes delivered to deficient liver and brain can mediate pervasive correction and illustrate the potential for gene therapy of MPS and other lysosomal storage diseases.