B
Beverly L. Davidson
Researcher at Children's Hospital of Philadelphia
Publications - 410
Citations - 35019
Beverly L. Davidson is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Gene silencing & RNA interference. The author has an hindex of 94, co-authored 391 publications receiving 33041 citations. Previous affiliations of Beverly L. Davidson include United States Department of Veterans Affairs & University of California, Los Angeles.
Papers
More filters
Journal ArticleDOI
Overexpression of interleukin-1 receptor antagonist in the mouse brain reduces ischemic brain injury.
TL;DR: These studies demonstrate that adenoviral vectors can be used to deliver genes to small animals such as mice and also suggest the feasibility of gene therapy for stroke and other neurological diseases.
Journal ArticleDOI
Striatal neurons directly converted from Huntington's disease patient fibroblasts recapitulate age-associated disease phenotypes.
Matheus B. Victor,Michelle Richner,Hannah E. Olsen,Seong Won Lee,Alex Mas Monteys,Chunyu Ma,Christine J. Huh,Bo Zhang,Beverly L. Davidson,Beverly L. Davidson,X. William Yang,Andrew S. Yoo +11 more
TL;DR: Direct neuronal conversion of skin fibroblasts from individuals with Huntington’s disease generates a population of medium spiny neurons that recapitulate hallmarks of HD, including aggregation of mutant huntingtin protein, DNA damage and spontaneous cell death.
Journal ArticleDOI
Silencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer's mice.
Diego Piedrahita,Israel Hernandez,Alejandro López-Tobón,Dmitry Fedorov,Boguslaw Obara,B.S. Manjunath,Ryan L. Boudreau,Beverly L. Davidson,Frank M. LaFerla,Juan Carlos Gallego-Gómez,Kenneth S. Kosik,Gloria Patricia Cardona-Gómez +11 more
TL;DR: Silencing of CDK5 reduces the phosphorylation of tau in primary neuronal cultures and in the brain of wild-type C57BL/6 mice, and the knockdown strongly decreased the number of neurofibrillary tangles in the hippocampi of triple-transgenic mice.
Journal ArticleDOI
Disease-associated short tandem repeats co-localize with chromatin domain boundaries
James H. Sun,Linda Zhou,Daniel J. Emerson,Sai Aung Phyo,Katelyn R. Titus,Wanfeng Gong,Thomas G. Gilgenast,Jonathan A. Beagan,Beverly L. Davidson,Flora Tassone,Jennifer E. Phillips-Cremins +10 more
TL;DR: It is discovered that nearly all disease-associated STRs (daSTRs) are located at boundaries demarcating 3D chromatin domains, and a subset of boundaries with markedly higher CpG island density compared to the rest of the genome are identified.
Journal ArticleDOI
Minimizing variables among hairpin-based RNAi vectors reveals the potency of shRNAs.
TL;DR: The results demonstrate that when comparison variables are minimized, the shRNAs tested were more potent than the artificial miRNAs in mediating gene silencing independent of target sequence and experimental setting (in vitro and in vivo).