Billie M. Moats-Staats

TL;DR: In this article, 32P-labeled complementary DNA probes encoding human and mouse Sm-C/IGF-I and human IGF-II were used in Northern blot hybridization to analyse rat SmC/I and insulin-like growth factor II mRNAs in poly(A+) RNAs from intestine, liver, lung, and brain of adults and fetal rats between day 14 and 17 of gestation.

TL;DR: The finding that Ubiquitin is synthesized as a precursor raises the possibility that the precursor sequence may be important in compartmentalization of ubiquitin or ubiquitIn precursors.

TL;DR: Analysis of gene expression in 20-day gestation liver and lung of growth-retarded fetuses did not support a role for decreased IGF or IGF receptor expression in the etiology of DXM-mediated growth retardation, and suggested that increased expression of IGFBP-1, and possibly IGF BP-2, is involved in mediating the marked growth retardedation.

TL;DR: The presence of a larger isoform of IGFBP-2 in a differentiation-dependent manner and a potentially novel IGFBP in response to IGF-I suggests that these IGFBPs may be important in modulating IGF- I action in adipogenesis.

TL;DR: The experience with a 1‐year‐old female with a kaposiform hemangioendothelioma and Kasabach–Merritt phenomenon who had rapid and dramatic response to sirolimus (0.1 mg/kg/day) provides further rationale for clinical trials of siro Limus in the treatment of vascular lesions.