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Billy T. Lau
Researcher at Stanford University
Publications - 50
Citations - 1745
Billy T. Lau is an academic researcher from Stanford University. The author has contributed to research in topics: Cancer & Biology. The author has an hindex of 13, co-authored 39 publications receiving 1273 citations. Previous affiliations of Billy T. Lau include Harvard University & ASTRON.
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Journal ArticleDOI
Haplotyping germline and cancer genomes with high-throughput linked-read sequencing
Grace X.Y. Zheng,Billy T. Lau,Michael Schnall-Levin,Mirna Jarosz,John Bell,Christopher Hindson,Sofia Kyriazopoulou-Panagiotopoulou,Donald A. Masquelier,Landon Merrill,Jessica M. Terry,Patrice A Mudivarti,Paul Wyatt,Rajiv Bharadwaj,Anthony J. Makarewicz,Yuan Li,Phillip Belgrader,Andrew D. Price,Adam Lowe,Patrick Marks,Gerard M Vurens,Paul Hardenbol,Luz Montesclaros,Melissa Luo,Lawrence Greenfield,Alexander Wong,David E Birch,Steven W Short,Keith Bjornson,Pranav Patel,Erik S. Hopmans,Christina Wood,Sukhvinder Kaur,Glenn K. Lockwood,David Stafford,Joshua Delaney,Indira Wu,Heather Ordonez,Susan M. Grimes,Stephanie Greer,Josephine Y Lee,Kamila Belhocine,Kristina Giorda,William Haynes Heaton,Geoffrey P. McDermott,Zachary Bent,Francesca Meschi,Nikola O Kondov,Ryan Wilson,Jorge Bernate,Shawn Gauby,Alex Kindwall,Clara Bermejo,Adrian Fehr,Adrian Chan,Serge Saxonov,Kevin D. Ness,Benjamin J. Hindson,Hanlee P. Ji +57 more
TL;DR: A microfluidics-based, linked-read sequencing technology that can phase and haplotypes generated from whole-genome sequencing of a primary colorectal adenocarcinoma and cancer genomes using nanograms of input DNA is presented.
Journal ArticleDOI
Correction to High Sensitivity Detection and Quantitation of DNA Copy Number and Single Nucleotide Variants with Single Color Droplet Digital PCR
TL;DR: This flexible and cost-effective method for quantifying copy number and point mutations utilizing a single-color, droplet digital PCR platform proves to be a robust alternative to the commercialized TaqMan assay.
Journal ArticleDOI
Single-Cell Genomic Characterization Reveals the Cellular Reprogramming of the Gastric Tumor Microenvironment.
Anuja Sathe,Susan M. Grimes,Billy T. Lau,Jiamin Chen,Carlos Suárez,Robert J. Huang,George A. Poultsides,Hanlee P. Ji +7 more
TL;DR: Single-cell gene expression studies revealed widespread reprogramming across multiple cellular elements in the gastric cancer TME, which facilitates understanding of tumor biology and enables identification of novel targets including for immunotherapy.
Journal ArticleDOI
A complete microfluidic screening platform for rational protein crystallization.
TL;DR: A complete microfluidic screening platform for protein crystallization that integrates fully programmable on-chip combinatorial mixing with dense assay storage using two-phase flows is described.
Journal ArticleDOI
Linked read sequencing resolves complex genomic rearrangements in gastric cancer metastases
Stephanie U. Greer,Lincoln Nadauld,Lincoln Nadauld,Billy T. Lau,Jiamin Chen,Christina Wood-Bouwens,James M. Ford,Calvin J. Kuo,Hanlee P. Ji +8 more
TL;DR: This study demonstrates that linked read sequencing is useful in characterizing oncogenic rearrangements in cancer metastasis and functionally validated the metastatic potential of an FGFR2 amplification in gastric cancer.