D
David Stafford
Publications - 3
Citations - 877
David Stafford is an academic researcher. The author has contributed to research in topics: Human genome & Shotgun sequencing. The author has an hindex of 3, co-authored 3 publications receiving 720 citations.
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Journal ArticleDOI
Haplotyping germline and cancer genomes with high-throughput linked-read sequencing
Grace X.Y. Zheng,Billy T. Lau,Michael Schnall-Levin,Mirna Jarosz,John Bell,Christopher Hindson,Sofia Kyriazopoulou-Panagiotopoulou,Donald A. Masquelier,Landon Merrill,Jessica M. Terry,Patrice A Mudivarti,Paul Wyatt,Rajiv Bharadwaj,Anthony J. Makarewicz,Yuan Li,Phillip Belgrader,Andrew D. Price,Adam Lowe,Patrick Marks,Gerard M Vurens,Paul Hardenbol,Luz Montesclaros,Melissa Luo,Lawrence Greenfield,Alexander Wong,David E Birch,Steven W Short,Keith Bjornson,Pranav Patel,Erik S. Hopmans,Christina Wood,Sukhvinder Kaur,Glenn K. Lockwood,David Stafford,Joshua Delaney,Indira Wu,Heather Ordonez,Susan M. Grimes,Stephanie Greer,Josephine Y Lee,Kamila Belhocine,Kristina Giorda,William Haynes Heaton,Geoffrey P. McDermott,Zachary Bent,Francesca Meschi,Nikola O Kondov,Ryan Wilson,Jorge Bernate,Shawn Gauby,Alex Kindwall,Clara Bermejo,Adrian Fehr,Adrian Chan,Serge Saxonov,Kevin D. Ness,Benjamin J. Hindson,Hanlee P. Ji +57 more
TL;DR: A microfluidics-based, linked-read sequencing technology that can phase and haplotypes generated from whole-genome sequencing of a primary colorectal adenocarcinoma and cancer genomes using nanograms of input DNA is presented.
Journal ArticleDOI
Resolving the full spectrum of human genome variation using Linked-Reads.
Patrick Marks,Sarah T. Garcia,Alvaro Martinez Barrio,Kamila Belhocine,Jorge Bernate,Rajiv Bharadwaj,Keith Bjornson,Claudia Catalanotti,Josh Delaney,Adrian Fehr,Ian T. Fiddes,Brendan Galvin,Haynes Heaton,Jill Herschleb,Christopher Hindson,Esty Holt,Cassandra B. Jabara,Susanna Jett,Nikka Keivanfar,Sofia Kyriazopoulou-Panagiotopoulou,Monkol Lek,Bill Kengli Lin,Adam Lowe,Shazia Mahamdallie,Shamoni Maheshwari,Tony Makarewicz,Jamie L. Marshall,Francesca Meschi,Christopher J. O'Keefe,Heather Ordonez,Pranav Patel,Andrew D. Price,Ariel Royall,Elise Ruark,Sheila Seal,Michael Schnall-Levin,Preyas Shah,David Stafford,Stephen R. Williams,Indira Wu,Andrew Wei Xu,Nazneen Rahman,Daniel G. MacArthur,Daniel G. MacArthur,Deanna M. Church +44 more
TL;DR: The data presented here show that Linked-Reads provide a scalable approach for comprehensive genome analysis that is not possible using short reads alone, and allows for simultaneous detection of small and large variants from a single library.
Patent
Systems and methods for visualizing structural variation and phasing information
TL;DR: In this article, a system for providing structural variation or phasing information from a nucleic acid sequence dataset is presented, where each sequencing read comprises a first portion corresponding to a subset of the target nucleic acids and a second portion that encodes an identifier for the sequencing read from a plurality of identifiers.