S
Susan M. Grimes
Researcher at Stanford University
Publications - 54
Citations - 1700
Susan M. Grimes is an academic researcher from Stanford University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 13, co-authored 38 publications receiving 1193 citations.
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Journal ArticleDOI
Haplotyping germline and cancer genomes with high-throughput linked-read sequencing
Grace X.Y. Zheng,Billy T. Lau,Michael Schnall-Levin,Mirna Jarosz,John Bell,Christopher Hindson,Sofia Kyriazopoulou-Panagiotopoulou,Donald A. Masquelier,Landon Merrill,Jessica M. Terry,Patrice A Mudivarti,Paul Wyatt,Rajiv Bharadwaj,Anthony J. Makarewicz,Yuan Li,Phillip Belgrader,Andrew D. Price,Adam Lowe,Patrick Marks,Gerard M Vurens,Paul Hardenbol,Luz Montesclaros,Melissa Luo,Lawrence Greenfield,Alexander Wong,David E Birch,Steven W Short,Keith Bjornson,Pranav Patel,Erik S. Hopmans,Christina Wood,Sukhvinder Kaur,Glenn K. Lockwood,David Stafford,Joshua Delaney,Indira Wu,Heather Ordonez,Susan M. Grimes,Stephanie Greer,Josephine Y Lee,Kamila Belhocine,Kristina Giorda,William Haynes Heaton,Geoffrey P. McDermott,Zachary Bent,Francesca Meschi,Nikola O Kondov,Ryan Wilson,Jorge Bernate,Shawn Gauby,Alex Kindwall,Clara Bermejo,Adrian Fehr,Adrian Chan,Serge Saxonov,Kevin D. Ness,Benjamin J. Hindson,Hanlee P. Ji +57 more
TL;DR: A microfluidics-based, linked-read sequencing technology that can phase and haplotypes generated from whole-genome sequencing of a primary colorectal adenocarcinoma and cancer genomes using nanograms of input DNA is presented.
Journal ArticleDOI
Intestinal enteroendocrine lineage cells possess homeostatic and injury-inducible stem cell activity
Kelley S. Yan,Kelley S. Yan,Olivier Gevaert,Grace X.Y. Zheng,Benedict Anchang,Chris Probert,Kathryn A. Larkin,Paige S. Davies,Zhuan fen Cheng,John S. Kaddis,Arnold Han,Arnold Han,Kelly Roelf,Ruben I. Calderon,Esther Cynn,Xiaoyi Hu,Komal Mandleywala,Julie Wilhelmy,Susan M. Grimes,David C Corney,Stéphane C. Boutet,Jessica M. Terry,Phillip Belgrader,Solongo B. Ziraldo,Tarjei S. Mikkelsen,Fengchao Wang,Richard J. von Furstenberg,Nicholas R. Smith,Parthasarathy Chandrakesan,Randal May,Mary Ann S. Chrissy,Rajan Jain,Christine A. Cartwright,Joyce C. Niland,Young-Kwon Hong,Jill L. Carrington,David T. Breault,Jonathan I. Epstein,Courtney W. Houchen,John P. Lynch,Martin G. Martin,Sylvia K. Plevritis,Christina Curtis,Hanlee P. Ji,Linheng Li,Susan J. Henning,Melissa H. Wong,Calvin J. Kuo +47 more
TL;DR: The data suggest that the EE lineage, including mature EE cells, comprises a reservoir of homeostatic and injury-inducible ISCs, extending the understanding of cellular plasticity and stemness.
Journal ArticleDOI
Single-Cell Genomic Characterization Reveals the Cellular Reprogramming of the Gastric Tumor Microenvironment.
Anuja Sathe,Susan M. Grimes,Billy T. Lau,Jiamin Chen,Carlos Suárez,Robert J. Huang,George A. Poultsides,Hanlee P. Ji +7 more
TL;DR: Single-cell gene expression studies revealed widespread reprogramming across multiple cellular elements in the gastric cancer TME, which facilitates understanding of tumor biology and enables identification of novel targets including for immunotherapy.
Journal ArticleDOI
The Cancer Genome Atlas Clinical Explorer: a web and mobile interface for identifying clinical–genomic driver associations
TL;DR: The Cancer Genome Atlas Clinical Explorer enables the cancer research community and others to explore clinically relevant associations inferred from TCGA data and identifies associations of potential clinical relevance among genes/micro RNAs/proteins across a broad spectrum of malignancies.
Journal ArticleDOI
Single-cell RNA-Seq of follicular lymphoma reveals malignant B-cell types and coexpression of T-cell immune checkpoints.
Noemi Andor,Erin F. Simonds,Debra K. Czerwinski,Jiamin Chen,Susan M. Grimes,Christina Wood-Bouwens,Grace X.Y. Zheng,Matthew Kubit,Stephanie Greer,William A. Weiss,Ronald Levy,Hanlee P. Ji +11 more
TL;DR: In this paper, the authors used multicolor flow cytometry analysis of the same tumors to confirm their assignments of cellular lineages and validate their predictions of expressed proteins, comparing gene expression between matched malignant and normal B cells from the same patient revealed tumorspecific features.