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Bin-Zhi Qian
Researcher at University of Edinburgh
Publications - 43
Citations - 11251
Bin-Zhi Qian is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Metastasis & Cancer. The author has an hindex of 22, co-authored 35 publications receiving 8834 citations. Previous affiliations of Bin-Zhi Qian include Guangzhou Medical University & Albert Einstein College of Medicine.
Papers
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Journal ArticleDOI
Macrophage Diversity Enhances Tumor Progression and Metastasis
Bin-Zhi Qian,Jeffrey W. Pollard +1 more
TL;DR: There is persuasive clinical and experimental evidence that macrophages promote cancer initiation and malignant progression, and specialized subpopulations of macrophage may represent important new therapeutic targets.
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CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
Bin-Zhi Qian,Jiufeng Li,Hui Zhang,Takanori Kitamura,Jinghang Zhang,Liam Campion,Elizabeth Kaiser,Linda A. Snyder,Jeffrey W. Pollard +8 more
TL;DR: The mechanistic link between CCL2 expression and macrophage infiltration are correlated with poor prognosis and metastatic disease in human breast cancer and the origin of these macrophages is defined by showing that Gr1-positive inflammatory monocytes are preferentially recruited to pulmonary metastases but not to primary mammary tumours in mice.
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Immune cell promotion of metastasis
TL;DR: How tumour-infiltrating immune cells contribute to the metastatic cascade is described and potential therapeutic strategies to target these cells are discussed.
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A Distinct Macrophage Population Mediates Metastatic Breast Cancer Cell Extravasation, Establishment and Growth
Bin-Zhi Qian,Yan Deng,Jae Hong Im,Ruth J. Muschel,Yiyu Zou,Jiufeng Li,Richard A. Lang,Jeffrey W. Pollard +7 more
TL;DR: Data indicate a direct enhancement of metastatic growth by macrophages through their effects on tumor cell extravasation, survival and subsequent growth and identifies these cells as a new therapeutic target for treatment of metastasis.
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CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages.
Takanori Kitamura,Bin-Zhi Qian,Daniel Soong,Luca Cassetta,Roy Noy,Gaël Sugano,Yu Kato,Jiufeng Li,Jeffrey W. Pollard,Jeffrey W. Pollard +9 more
TL;DR: Genetic deletion of CCR1 or CCL3 in a mouse model of breast cancer cell metastasis prevents MAM retention in the lung, reduces MAM-cancer cell interactions and reduces the number of lung metastatic foci.