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Bin-Zhi Qian
Researcher at University of Edinburgh
Publications - 43
Citations - 11251
Bin-Zhi Qian is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Metastasis & Cancer. The author has an hindex of 22, co-authored 35 publications receiving 8834 citations. Previous affiliations of Bin-Zhi Qian include Guangzhou Medical University & Albert Einstein College of Medicine.
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Prostaglandin E2 promotes intestinal inflammation via inhibiting microbiota-dependent regulatory T cells
Siobhan Crittenden,Marie Goepp,Jolinda Pollock,Calum T. Robb,Danielle J. Smyth,You Zhou,Robert Andrews,Victoria J. Tyrrell,Alexander Adima,Richard A. O’Connor,Luke C. Davies,Xue-Feng Li,Hatti X. Yao,Gwo-Tzer Ho,Xiaozhong Zheng,Amil Mair,Sonja Vermeren,Bin-Zhi Qian,Damian J. Mole,Jürgen Schwarze,Richard M. Breyer,Mark J. Arends,Valerie B. O'Donnell,John P. Iredale,Stephen M. Anderton,Shuh Narumiya,Rick M. Maizels,Adriano G. Rossi,Sarah E. M. Howie,Chengcan Yao +29 more
TL;DR: It is reported that prostaglandin E2 (PGE2) inhibits mucosal Tregs in a manner depending on the gut microbiota, and PGE2 through its receptor EP4 diminishes Treg-favorable commensal microbiota.
Journal ArticleDOI
A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability.
Carolin Temps,Daniel Lietha,Emily R. Webb,Xue-Feng Li,John C. Dawson,Morwenna Muir,Kenneth G. MacLeod,Teresa Valero,Alison F. Munro,Rafael Contreras-Montoya,Juan Román Luque-Ortega,Craig Fraser,Henry Beetham,Christina Schoenherr,Maria Lopalco,Mark J. Arends,Margaret C. Frame,Bin-Zhi Qian,Valerie G. Brunton,Neil O. Carragher,Asier Unciti-Broceta +20 more
TL;DR: CF506 as mentioned in this paper locks SRC in its native inactive conformation, thereby inhibiting both enzymatic and scaffolding functions that prevent phosphorylation and complex formation with its partner FAK.
Journal ArticleDOI
Interleukin 4 Controls the Pro-Tumoral Role of Macrophages in Mammary Cancer Pulmonary Metastasis in Mice
Carolina Rodriguez-Tirado,David Entenberg,Jiufeng Li,Bin-Zhi Qian,John S. Condeelis,Jeffrey W. Pollard +5 more
TL;DR: It is concluded that IL4 signaling in monocytes and macrophages is important during seeding and growth of breast metastasis in the lung, as it regulates pro-tumoral paracrine signaling between cancer cells andmacrophages.
Journal ArticleDOI
MYC sensitises cells to apoptosis by driving energetic demand
Joy Edwards-Hicks,Hui-xuan Su,Maurizio Mangolini,Kubra Karaosmanoglu Yoneten,Jimi Wills,Giovanny Rodríguez-Blanco,Christine S. Young,Kevin Cho,Heather Barker,Morwenna Muir,Ania Naila Guerrieri,Xue-Feng Li,Rachel White,Piotr Manasterski,Elena Mandrou,Karen L H Wills,Jingyu Chen,Emily Abraham,Kianoosh Sateri,Bin-Zhi Qian,Peter Bankhead,Mark J. Arends,Noor Gammoh,Alex von Kriegsheim,Gary J. Patti,Andrew H. Sims,Juan Carlos Acosta,Valerie G. Brunton,Kamil R. Kranc,Maria A. Christophorou,Erika L. Pearce,Ingo Ringshausen,Andrew J. Finch +32 more
TL;DR: In this article , it was shown that the MYC oncogene is a potent driver of growth and proliferation but also sensitises cells to apoptosis, which limits its oncogenic potential.
Proceedings ArticleDOI
Abstract 2842: CCL2 recruits inflammatory monocytes to facilitate breast tumor metastasis
TL;DR: The data strongly suggest that recruitment of Ly6C+ inflammatory monocytes is the mechanistic link between these two clinical associations and suggests new therapeutic targets for treating metastatic breast disease.