Bin-Zhi Qian

TL;DR: Show that VEGFA signaling from TIE2(hi) TMEM macrophages results in local, transient vascular permeability and tumor cell intravasation, providing evidence for the mechanism underlying the association of TMEM with distant metastatic recurrence, offering a rationale for therapies targeting TMEM.

TL;DR: In this paper, a comprehensive characterization of gene expression profiles of hepatitis B virus-positive HCC through the generation of a large set of 5′-read expressed sequence tag (EST) clusters (11,065 in total) from HCC and non-cancerous liver samples, which then were applied to a cDNA microarray system containing 12,393 genes/ESTs and to comparison with a public database.

TL;DR: This work reports that an alternatively activated (M2) subpopulation of TAMs accumulate around blood vessels in tumors after chemotherapy, where they promote tumor revascularization and relapse, in part, via VEGF-A release and rationalizes a strategy to leverage chemotherapeutic efficacy by selectively targeting this perivascular, relapse-promoting M2-related TAM cell population.

TL;DR: The currently available mouse models of metastasis are described, focusing on the mechanistic and therapeutic insights that have been gained by their application, strengths and weaknesses of different models and key technological advances that are generating more refined models.

TL;DR: TIGIT blockade enhances the cytotoxicity effects of the primary CD3+ T cells with high proportion of TIGIT+ cells against osteosarcoma, and provides potential therapeutic targets for osteosARcoma.