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Bin Zuo
Researcher at Shanghai Jiao Tong University
Publications - 13
Citations - 381
Bin Zuo is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: RANKL & Aggrecan. The author has an hindex of 6, co-authored 12 publications receiving 286 citations.
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Journal ArticleDOI
microRNA‐103a Functions as a Mechanosensitive microRNA to Inhibit Bone Formation Through Targeting Runx2
Bin Zuo,Junfeng Zhu,Jiao Li,Chuandong Wang,Xiaoying Zhao,Guiquan Cai,Zheng Li,Jianping Peng,Peng Wang,Chao Shen,Yan Huang,Jiake Xu,Xiaoling Zhang,Xiaodong Chen +13 more
TL;DR: The data suggest that miR‐103a is the first identified mechanosensitive miRNA that regulates osteoblast differentiation by directly targeting Runx2, and therapeutic inhibition of miR-103a may be an efficient anabolic strategy for skeletal disorders caused by pathological mechanical loading.
Journal ArticleDOI
MicroRNA-145 attenuates TNF- α -driven cartilage matrix degradation in osteoarthritis via direct suppression of MKK4
Guoli Hu,Xiaoying Zhao,Chuandong Wang,Yiyun Geng,Jingyu Zhao,Jiajia Xu,Bin Zuo,Chen Zhao,Chenglong Wang,Xiaoling Zhang +9 more
TL;DR: A novel regulatory mechanism underlying TNF-α-triggered cartilage degradation is elucidated and the potential utility of miR-145 and MKK4 as therapy targets for OA is demonstrated.
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Gremlin2 Suppression Increases the BMP-2-Induced Osteogenesis of Human Bone Marrow-Derived Mesenchymal Stem Cells Via the BMP-2/Smad/Runx2 Signaling Pathway.
Chenglong Wang,Fei Xiao,Chuandong Wang,Junfeng Zhu,Chao Shen,Bin Zuo,Hui Wang,De Li,X. Wang,Wei-Jia Feng,Zhuokai Li,Guoli Hu,Xiaoling Zhang,Xiaodong Chen +13 more
TL;DR: It was found that Grem2 expression was upregulated by BMP‐2 within the range of 0–1 μg/mL, and significant increases were evident at 48, 72, and 96 h after B MP‐2 treatment, whereas overexpression of Gremlin2 had the opposite trend.
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Exosomes derived from cyclic mechanical stretch-exposed bone marrow mesenchymal stem cells inhibit RANKL-induced osteoclastogenesis through the NF-κB signaling pathway
Fei Xiao,Bin Zuo,Bo Tao,Chuandong Wang,Yang Li,Jianping Peng,Chao Shen,Yiming Cui,Junfeng Zhu,Xiaodong Chen +9 more
TL;DR: This year's Shanghai Jiaotong University School of Medicine graduation ceremony marked the 50th anniversary of the establishment of the university and marked the start of a new era in Chinese medical education.
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Nano-sized Al 2 O 3 particle-induced autophagy reduces osteolysis in aseptic loosening of total hip arthroplasty by negative feedback regulation of RANKL expression in fibroblasts
De Li,Chenglong Wang,Zhuokai Li,Hui Wang,Jiye He,Junfeng Zhu,Yue-Hui Zhang,Chao Shen,Fei Xiao,Yuan Gao,Xiang Zhang,Yang Li,Peng Wang,Jianping Peng,Guiquan Cai,Bin Zuo,Yuehua Yang,Yun Shen,Weidong Song,Xiaoling Zhang,Lei Shen,Xiaodong Chen +21 more
TL;DR: Investigating the relationship between RANKL levels in patients experiencing aseptic loosening after total hip arthroplasty and hip osteoarthritis and the effects of Al2O3 particles on autophagy levels and RankL expression in synovial tissues in vivo confirmed the findings of in vitro and in vivo.