R
Ruifu Yang
Researcher at Academy of Military Medical Sciences
Publications - 390
Citations - 21362
Ruifu Yang is an academic researcher from Academy of Military Medical Sciences. The author has contributed to research in topics: Yersinia pestis & Gene. The author has an hindex of 59, co-authored 355 publications receiving 17586 citations. Previous affiliations of Ruifu Yang include Beijing Genomics Institute & Chinese Academy of Sciences.
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Journal ArticleDOI
A metagenome-wide association study of gut microbiota in type 2 diabetes
Junjie Qin,Yingrui Li,Zhiming Cai,Shenghui Li,Jianfeng Zhu,Fan Zhang,Suisha Liang,Wenwei Zhang,Yuanlin Guan,Dongqian Shen,Yangqing Peng,Dongya Zhang,Zhuye Jie,Wenxian Wu,Youwen Qin,Wenbin Xue,Junhua Li,Lingchuan Han,Donghui Lu,Peixian Wu,Yali Dai,Xiaojuan Sun,Zesong Li,Aifa Tang,Shilong Zhong,Xiaoping Li,Weineng Chen,Ran Xu,Mingbang Wang,Qiang Feng,Meihua Gong,Jing Yu,Yanyan Zhang,Ming Zhang,Torben Hansen,Gaston Sanchez,Jeroen Raes,Gwen Falony,Shujiro Okuda,Mathieu Almeida,Emmanuelle Le-chatelier,Pierre Renault,Nicolas Pons,Jean-Michel Batto,Zhaoxi Zhang,Hua Chen,Ruifu Yang,Wei-Mou Zheng,Songgang Li,Huanming Yang,Jian Wang,S. Dusko Ehrlich,Rasmus Nielsen,Oluf Pedersen,Oluf Pedersen,Karsten Kristiansen,Jun Wang +56 more
TL;DR: MGWAS analysis showed that patients with type 2 diabetes were characterized by a moderate degree of gut microbial dysbiosis, a decrease in the abundance of some universal butyrate-producing bacteria and an increase in various opportunistic pathogens, as well as an enrichment of other microbial functions conferring sulphate reduction and oxidative stress resistance.
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An investigation of transmission control measures during the first 50 days of the COVID-19 epidemic in China.
Huaiyu Tian,Yonghong Liu,Yidan Li,Chieh-Hsi Wu,Bin Chen,Moritz U. G. Kraemer,Moritz U. G. Kraemer,Bingying Li,Jun Cai,Bo Xu,Qiqi Yang,Ben Wang,Peng Yang,Yujun Cui,Yimeng Song,Pai Zheng,Quanyi Wang,Ottar N. Bjørnstad,Ruifu Yang,Bryan T. Grenfell,Bryan T. Grenfell,Oliver G. Pybus,Christopher Dye +22 more
TL;DR: The national emergency response appears to have delayed the growth and limited the size of the COVID-19 epidemic in China, averting hundreds of thousands of cases by 19 February (day 50), and suspending intracity public transport, closing entertainment venues, and banning public gatherings were associated with reductions in case incidence.
Journal ArticleDOI
Metagenome-wide analysis of antibiotic resistance genes in a large cohort of human gut microbiota
Yongfei Hu,Xi Yang,Junjie Qin,Na Lu,Gong Cheng,Na Wu,Yuanlong Pan,Jing Li,Liying Zhu,Xin Wang,Zhiqi Meng,Fangqing Zhao,Di Liu,Juncai Ma,Nan Qin,Chunsheng Xiang,Yonghong Xiao,Lanjuan Li,Huanming Yang,Jian Wang,Ruifu Yang,George F. Gao,Jun Wang,Baoli Zhu +23 more
TL;DR: It is found that Chinese individuals harbour the highest number and abundance of antibiotic resistance genes, followed by Danish and Spanish individuals, and single-nucleotide polymorphism-based analysis indicates that antibiotic resistant genes from the two European populations are more closely related while the Chinese ones are clustered separately.
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Yersinia pestis genome sequencing identifies patterns of global phylogenetic diversity
Giovanna Morelli,Yajun Song,Yajun Song,Camila J. Mazzoni,Mark Eppinger,Philippe Roumagnac,David M. Wagner,Mirjam Feldkamp,Barica Kusecek,Amy J. Vogler,Yanjun Li,Yujun Cui,Nicholas R. Thomson,Thibaut Jombart,Raphaël Leblois,Peter Lichtner,Lila Rahalison,Jeannine M. Petersen,Francois Balloux,Paul Keim,Paul Keim,Thierry Wirth,Jacques Ravel,Ruifu Yang,Elisabeth Carniel,Mark Achtman +25 more
TL;DR: The phylogenetic analysis suggests that Y. pestis evolved in or near China and spread through multiple radiations to Europe, South America, Africa and Southeast Asia, leading to country-specific lineages that can be traced by lineage-specific SNPs.
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Open-Source Genomic Analysis of Shiga-Toxin–Producing E. coli O104:H4
Holger Rohde,Junjie Qin,Yujun Cui,Dongfang Li,Nicholas J. Loman,Moritz Hentschke,Wentong Chen,Fei Pu,Yangqing Peng,Junhua Li,Feng Xi,Shenghui Li,Yin Li,Zhaoxi Zhang,Xianwei Yang,Meiru Zhao,Peng Wang,Yuanlin Guan,Zhong Cen,Xiangna Zhao,Martin Christner,Robin Kobbe,Sebastian Loos,Jun Oh,Liang Yang,Antoine Danchin,George F. Gao,Yajun Song,Yingrui Li,Huanming Yang,Jian Wang,Jianguo Xu,Mark J. Pallen,Jun Wang,Martin Aepfelbacher,Ruifu Yang +35 more
TL;DR: A cluster of cases associated with a single family is reported and an open-source genomic analysis of an isolate from one member of the family is described, revealing that the outbreak strain belonged to an enteroaggregative E. coli lineage that had acquired genes for Shiga toxin 2 and for antibiotic resistance.