Bingqian Lin

TL;DR: This study identified high-binding-affinity aptamers targeting SARS-CoV-2 RBD, using an ACE2 competition-based aptamer selection strategy and a machine learning screening algorithm, and suggests that two aptamer may have partially identical binding sites at ACE2 on Sars- coV- 2 RBD.

TL;DR: A broad overview of aptamer-based liquid biopsy techniques for precision medicine can be found in this article, where the authors present a summary of state-of-the-art strategies for multivalent aptamer assembly and aptamer interface modification.

TL;DR: The transport efficiency of PSiNPs across BBB was found to be size-dependent, with increased particle size resulting in decreased efficiency, which points to the potential application of small sized silica nanoparticles in brain imaging or drug delivery.

TL;DR: Zhang et al. as mentioned in this paper developed a dual target-specific aptamer recognition activated in situ connection system on exosome membrane combined with droplet digital PCR (ddPCR) (TRACER) for quantification of tumor-derived exosomal PD-L1 (Exo-PD-L 1 ).

TL;DR: A board definition of the biosensor or biosensing system that incorporates any method coupling these two key elements, and ultimately achieving "sample-in-answer-out" is provided.