B
Birgit Korioth-Schmitz
Researcher at Beth Israel Deaconess Medical Center
Publications - 24
Citations - 1538
Birgit Korioth-Schmitz is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Simian immunodeficiency virus & Virus. The author has an hindex of 16, co-authored 24 publications receiving 1475 citations. Previous affiliations of Birgit Korioth-Schmitz include Harvard University.
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Journal ArticleDOI
Immunogenicity of Recombinant Adenovirus Serotype 35 Vaccine in the Presence of Pre-Existing Anti-Ad5 Immunity
Dan H. Barouch,Maria G. Pau,Jerome Custers,Wouter Koudstaal,Stefan Kostense,Menzo J. E. Havenga,Diana M. Truitt,Shawn M. Sumida,Michael G. Kishko,Janelle C. Arthur,Birgit Korioth-Schmitz,Michael H. Newberg,Darci A. Gorgone,Michelle A. Lifton,Dennis Panicali,Gary J. Nabel,Norman L. Letvin,Jaap Goudsmit +17 more
TL;DR: The potential utility of Ad35 as a candidate vaccine vector that is minimally suppressed by anti-Ad5 immunity is demonstrated and studies suggest that using Ad vectors derived from immunologically distinct serotypes may be an effective and general strategy to overcome the suppressive effects of pre-existing anti- Ad immunity.
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Effect of Preexisting Immunity to Adenovirus Human Serotype 5 Antigens on the Immune Responses of Nonhuman Primates to Vaccine Regimens Based on Human- or Chimpanzee-Derived Adenovirus Vectors
Kimberly C. McCoy,Nia Tatsis,Birgit Korioth-Schmitz,Marcio O. Lasaro,Scott E. Hensley,Shih-Wen Lin,Yan Li,Wynetta Giles-Davis,Ann Cun,Dongming Zhou,Zhiquan Xiang,Norman L. Letvin,Hildegund C.J. Ertl +12 more
TL;DR: Results indicate that analysis of T-cell responses solely from blood mononuclear cells of vaccine recipients may not suffice to compare the potencies of different vaccine regimens, and changes the homing pattern of vaccine-induced T cells are changed.
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A Human T-Cell Leukemia Virus Type 1 Regulatory Element Enhances the Immunogenicity of Human Immunodeficiency Virus Type 1 DNA Vaccines in Mice and Nonhuman Primates
Dan H. Barouch,Zhi Yong Yang,Wing Pui Kong,Birgit Korioth-Schmitz,Shawn M. Sumida,Diana M. Truitt,Michael G. Kishko,Janelle C. Arthur,Ayako Miura,John R. Mascola,Norman L. Letvin,Gary J. Nabel +11 more
TL;DR: Optimization of specific regulatory elements in the plasmid backbone can substantially improve the immunogenicity of DNA vaccines encoding multiple antigens in small animals and in nonhuman primates.
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Heterologous Envelope Immunogens Contribute to AIDS Vaccine Protection in Rhesus Monkeys
Norman L. Letvin,Norman L. Letvin,Yue Huang,Bimal K. Chakrabarti,Ling Xu,Michael S. Seaman,Kristin Beaudry,Birgit Korioth-Schmitz,Faye Yu,Daniela Rohne,Kristi L. Martin,Ayako Miura,Wing Pui Kong,Zhi Yong Yang,Rebecca Gelman,Olga G. Golubeva,David C. Montefiori,John R. Mascola,Gary J. Nabel +18 more
TL;DR: It is suggested that T-lymphocyte immunity to Env can broaden the protective cellular immune response to HIV despite significant sequence diversity of the strains of the Env immunogens and can contribute to immune protection in this AIDS vaccine model.
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A Replication-Competent Adenovirus-Human Immunodeficiency Virus (Ad-HIV) tat and Ad-HIV env Priming/Tat and Envelope Protein Boosting Regimen Elicits Enhanced Protective Efficacy against Simian/Human Immunodeficiency Virus SHIV89.6P Challenge in Rhesus Macaques
Thorsten Demberg,Ruth H. Florese,Megan J. Heath,Kay Larsen,Irene Kalisz,Vaniambadi S. Kalyanaraman,Eun Mi Lee,Ranajit Pal,David Venzon,Richard Grant,L. Jean Patterson,Birgit Korioth-Schmitz,Adam P. Buzby,Dilani Dombagoda,David C. Montefiori,Norman L. Letvin,Aurelio Cafaro,Barbara Ensoli,Marjorie Robert-Guroff +18 more
TL;DR: Priming rhesus macaques with replicating Ad-human immunodeficiency virus (HIV) tat and boosting with the Tat protein would elicit protection against SHIV89.6P, and other functional anti-Env and anti-Tat activities are under investigation, as is a possible synergy between the Tat and Env immunogens.