Aurelio Cafaro

TL;DR: Basic fibroblast growth factor and human immunodeficiency virus type 1 (HIV-1) Tat protein synergize in inducing angiogenic Kaposi's sarcoma-like lesions in mice, which may explain the higher frequency and aggressiveness of this form of KS.

TL;DR: Systemic administration of the PIs indinavir or saquinavir to nude mice blocks the development and induces regression of angioproliferative KS-like lesions promoted by primary human KS cells, basic fibroblast growth factor, or bFGF and vascular endothelial growth factor combined.

TL;DR: It is shown that vaccination of cynomolgus monkeys with a biologically active HIV-1 Tat protein is safe, elicits a broad (humoral and cellular) specific immune response and reduces infection with the highly pathogenic simian-human immunodeficiency virus (SHIV)-89.6P to undetectable levels, preventing the CD4+ T-cell decrease.

TL;DR: The results indicate that PBMC that are polymerase chain reaction (PCR)-positive at day 0 generally loose the virus upon culture, and suggest that infected monocytes may carry the virus to tissues, transmit the infection, or differentiate in loco in spindle cells with endothelial macrophage markers.

TL;DR: It is shown that biologically active Tat is very efficiently taken up by monocyte-derived dendritic cells (MDDC) in a time- and dose-dependent fashion, whereas uptake is very poor or absent with other APC, including T cell blasts and B lymphoblastoid cell lines.