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Adam P. Buzby
Researcher at Beth Israel Deaconess Medical Center
Publications - 17
Citations - 1429
Adam P. Buzby is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Simian immunodeficiency virus & Virus. The author has an hindex of 13, co-authored 17 publications receiving 1395 citations. Previous affiliations of Adam P. Buzby include Harvard University.
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Journal ArticleDOI
Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys.
Norman L. Letvin,John R. Mascola,Yue Sun,Darci A. Gorgone,Adam P. Buzby,Ling Xu,Zhi Yong Yang,Bimal K. Chakrabarti,Srinivas S. Rao,Jörn E. Schmitz,David C. Montefiori,Brianne R. Barker,Fred L. Bookstein,Gary J. Nabel +13 more
TL;DR: Although these monkeys demonstrated a reduction in viremia restricted to the early phase of SIV infection, they showed a prolonged survival that could be predicted by the magnitude of the vaccine-induced cellular immune response, which should guide the evaluation of AIDS vaccines in humans.
Journal ArticleDOI
Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys.
Sampa Santra,Hua-Xin Liao,Ruijin Zhang,Mark Muldoon,Sydeaka Watson,Sydeaka Watson,Will Fischer,James Theiler,James J. Szinger,Harikrishnan Balachandran,Adam P. Buzby,David S Quinn,Robert Parks,Chun-Yen Tsao,Angela Carville,Keith G. Mansfield,George N. Pavlakis,Barbara K. Felber,Barton F. Haynes,Bette T. Korber,Bette T. Korber,Norman L. Letvin +21 more
TL;DR: Increased breadth and depth of epitope recognition may contribute both to protection against infection by genetically diverse viruses and to the control of variant viruses that emerge as they mutate away from recognition by cytotoxic T lymphocytes.
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Immune and Genetic Correlates of Vaccine Protection Against Mucosal Infection by SIV in Monkeys
Norman L. Letvin,Srinivas S. Rao,David C. Montefiori,Michael S. Seaman,Yue Sun,So-Yon Lim,Wendy W. Yeh,Mohammed Asmal,Rebecca Gelman,Ling Shen,James B. Whitney,Cathal Seoighe,Miguel Lacerda,Miguel Lacerda,Sheila M. Keating,Philip J. Norris,Michael G. Hudgens,Peter B. Gilbert,Adam P. Buzby,Linh Mach,Jinrong Zhang,Harikrishnan Balachandran,George M. Shaw,Stephen D. Schmidt,John Paul Todd,Alan Dodson,John R. Mascola,Gary J. Nabel +27 more
TL;DR: A vaccine protecting monkeys against mucosal infection by simian immunodeficiency virus sheds light on immune and genetic correlates of protection and highlights the need to scrutinize these types of correlates in future trials of HIV vaccines in human volunteers.
Journal ArticleDOI
Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV
Mario Roederer,Brandon F. Keele,Stephen D. Schmidt,Rosemarie D. Mason,Hugh C. Welles,Hugh C. Welles,Will Fischer,Celia C. LaBranche,Kathryn E. Foulds,Mark K. Louder,Zhi-Yong Yang,Zhi-Yong Yang,John Paul Todd,Adam P. Buzby,Linh Mach,Ling Shen,Kelly E. Seaton,Brandy M. Ward,Robert T. Bailer,Raphael Gottardo,Wenjuan Gu,Guido Ferrari,S. Munir Alam,Thomas N. Denny,David C. Montefiori,Georgia D. Tomaras,Bette T. Korber,Martha Nason,Robert A. Seder,Richard A. Koup,Norman L. Letvin,Srinivas S. Rao,Gary J. Nabel,Gary J. Nabel,John R. Mascola +34 more
TL;DR: A nonhuman primate challenge model with simian immunodeficiency virus (SIV) shows that antibodies to the SIV envelope are necessary and sufficient to prevent infection, and identifies a two-amino-acid signature that alters antigenicity and confers neutralization resistance.
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A Replication-Competent Adenovirus-Human Immunodeficiency Virus (Ad-HIV) tat and Ad-HIV env Priming/Tat and Envelope Protein Boosting Regimen Elicits Enhanced Protective Efficacy against Simian/Human Immunodeficiency Virus SHIV89.6P Challenge in Rhesus Macaques
Thorsten Demberg,Ruth H. Florese,Megan J. Heath,Kay Larsen,Irene Kalisz,Vaniambadi S. Kalyanaraman,Eun Mi Lee,Ranajit Pal,David Venzon,Richard Grant,L. Jean Patterson,Birgit Korioth-Schmitz,Adam P. Buzby,Dilani Dombagoda,David C. Montefiori,Norman L. Letvin,Aurelio Cafaro,Barbara Ensoli,Marjorie Robert-Guroff +18 more
TL;DR: Priming rhesus macaques with replicating Ad-human immunodeficiency virus (HIV) tat and boosting with the Tat protein would elicit protection against SHIV89.6P, and other functional anti-Env and anti-Tat activities are under investigation, as is a possible synergy between the Tat and Env immunogens.