B
Bo W. Han
Researcher at University of Massachusetts Medical School
Publications - 12
Citations - 1452
Bo W. Han is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Piwi-interacting RNA & Argonaute. The author has an hindex of 10, co-authored 11 publications receiving 1263 citations.
Papers
More filters
Journal ArticleDOI
An Ancient Transcription Factor Initiates the Burst of piRNA Production during Early Meiosis in Mouse Testes
Xin Zhiguo Li,Christian K. Roy,Xianjun Dong,Ewelina Bolcun-Filas,Jie Wang,Bo W. Han,Jia Xu,Melissa J. Moore,John C. Schimenti,Zhiping Weng,Phillip D. Zamore +10 more
TL;DR: It is shown that the transcription factor A-MYB initiates pachytene piRNA production and regulation of piRNA pathway proteins and piRNA genes creates a coherent feedforward loop that ensures the robust accumulation of pachyTene piRNAs.
Journal ArticleDOI
piRNA-guided transposon cleavage initiates Zucchini-dependent, phased piRNA production
TL;DR: It is reported that secondary piRNAs, bound to the PIWI protein Ago3, can initiate primary piRNA production from cleaved transposon RNAs, andPhased synthesis of germline-protective pi RNAs along precursor RNAs increases piRNA sequence diversity.
Journal ArticleDOI
Dicer Partner Proteins Tune the Length of Mature miRNAs in Flies and Mammals
TL;DR: Dicer-binding partner proteins change the choice of cleavage site by Dicer, producing miRNAs with target specificities different from those made by Diter alone or Dicer bound to alternative protein partners.
Journal ArticleDOI
The 3'-to-5' exoribonuclease Nibbler shapes the 3' ends of microRNAs bound to Drosophila Argonaute1.
TL;DR: A molecular explanation for the previously reported heterogeneity of miRNA 3' ends is provided and a model in which Nibbler converts miRNAs into isoforms that are compatible with the preferred length of Ago1-bound small RNAs is proposed.
Journal ArticleDOI
piPipes: a set of pipelines for piRNA and transposon analysis via small RNA-seq, RNA-seq, degradome- and CAGE-seq, ChIP-seq and genomic DNA sequencing
TL;DR: A coordinated set of pipelines, ‘piPipes’, to analyze piRNA and transposon-derived RNAs from a variety of high-throughput sequencing libraries, including small RNA, RNA, degradome or 7-methyl guanosine cap analysis of gene expression (CAGE), chromatin immunoprecipitation (ChIP) and genomic DNA-seq.