X
Xin Zhiguo Li
Researcher at University of Rochester Medical Center
Publications - 18
Citations - 1532
Xin Zhiguo Li is an academic researcher from University of Rochester Medical Center. The author has contributed to research in topics: Piwi-interacting RNA & RNA. The author has an hindex of 7, co-authored 16 publications receiving 1188 citations. Previous affiliations of Xin Zhiguo Li include University of Rochester & University of Massachusetts Medical School.
Papers
More filters
Journal ArticleDOI
Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals
Upasna Sharma,Colin C. Conine,Jeremy M. Shea,Ana Bošković,Alan G. Derr,Xin Y. Bing,Clémence Belleannée,Alper Kucukural,Ryan W. Serra,Fengyun Sun,Lina Song,Benjamin R. Carone,Emiliano P. Ricci,Xin Zhiguo Li,Lucas Fauquier,Melissa J. Moore,Robert Sullivan,Craig C. Mello,Manuel Garber,Oliver J. Rando +19 more
TL;DR: The results shed light on sRNA biogenesis and its dietary regulation during posttesticular sperm maturation, and they also link tRNA fragments to regulation of endogenous retroelements active in the preimplantation embryo.
Journal ArticleDOI
An Ancient Transcription Factor Initiates the Burst of piRNA Production during Early Meiosis in Mouse Testes
Xin Zhiguo Li,Christian K. Roy,Xianjun Dong,Ewelina Bolcun-Filas,Jie Wang,Bo W. Han,Jia Xu,Melissa J. Moore,John C. Schimenti,Zhiping Weng,Phillip D. Zamore +10 more
TL;DR: It is shown that the transcription factor A-MYB initiates pachytene piRNA production and regulation of piRNA pathway proteins and piRNA genes creates a coherent feedforward loop that ensures the robust accumulation of pachyTene piRNAs.
Journal ArticleDOI
Cnidarian microRNAs frequently regulate targets by cleavage
Yehu Moran,David Fredman,Daniela Praher,Xin Zhiguo Li,Liang Meng Wee,Fabian Rentzsch,Phillip D. Zamore,Ulrich Technau,Hervé Seitz +8 more
TL;DR: It is proposed that post-transcriptional regulation by miRNAs functions differently in Cnidaria and Bilateria, as several of the miRNA target sites are conserved among distantly related anemone species, and miRNA-directed cleavage in Hydra is detected.
Journal ArticleDOI
Domestic chickens activate a piRNA defense against avian leukosis virus
Yu H. Sun,Li Huitong Xie,Xiaoyu Zhuo,Qiang Chen,Dalia Ghoneim,Bin Zhang,Jarra Jagne,Chengbo Yang,Xin Zhiguo Li +8 more
TL;DR: The findings uncover rapid piRNA evolution reflecting contemporary TE activity, identify a new piRNA acquisition modality by activating a pre-existing genomic locus, and extend piRNA defense roles to include the period when endogenous retroviruses are still infectious.
Journal ArticleDOI
Single-molecule long-read sequencing reveals a conserved intact long RNA profile in sperm
Yu H. Sun,Anqi Wang,Chi Song,Goutham Shankar,Rajesh K. Srivastava,Kin Fai Au,Xin Zhiguo Li,Xin Zhiguo Li +7 more
TL;DR: In this paper, the authors integrate single-molecule long-read sequencing with short read sequencing to detect sperm intact RNAs (spiRNAs) and identify 3440 spiRNA species in mice and 4100 in humans.