B
Boris Engels
Researcher at Novartis
Publications - 54
Citations - 3089
Boris Engels is an academic researcher from Novartis. The author has contributed to research in topics: T cell & Chimeric antigen receptor. The author has an hindex of 25, co-authored 51 publications receiving 2619 citations. Previous affiliations of Boris Engels include University of Illinois at Chicago & University of Chicago.
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Journal ArticleDOI
Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma.
Avery D. Posey,Robert D. Schwab,Alina C. Boesteanu,Catharina Steentoft,Ulla Mandel,Boris Engels,Jennifer D. Stone,Thomas Daugbjerg Madsen,Karin Schreiber,Kathleen M. Haines,Alexandria P. Cogdill,Taylor J. Chen,Decheng Song,John Scholler,David M. Kranz,Michael Feldman,Regina M. Young,Brian Keith,Hans Schreiber,Henrik Clausen,Laura A. Johnson,Carl H. June +21 more
TL;DR: This work developed a CAR that recognized cancer-associated Tn glycoform of MUC1, a neoantigen expressed in a variety of cancers and established that abnormal self-antigens can serve as targets for tumor rejection.
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Rational development and characterization of humanized anti–EGFR variant III chimeric antigen receptor T cells for glioblastoma
Laura A. Johnson,John Scholler,Takayuki Ohkuri,Akemi Kosaka,Prachi R. Patel,Shannon E. McGettigan,Arben Nace,Tzvete Dentchev,Pramod Thekkat,Andreas Loew,Alina C. Boesteanu,Alexandria P. Cogdill,Taylor Chen,Joseph A. Fraietta,Christopher C. Kloss,Avery D. Posey,Boris Engels,Reshma Singh,Tucker Ezell,Neeraja Idamakanti,Melissa Ramones,Na Li,Li Zhou,Gabriela Plesa,John T. Seykora,Hideho Okada,Carl H. June,Jennifer Brogdon,Marcela V. Maus +28 more
TL;DR: A low-affinity single-chain variable fragment was specific for EGFRvIII over wild-type EGFR and CAR T cells transduced with this fragment were able to target antigen-expressing cells in vitro and in vivo in multiple mouse xenograft models of human glioblastoma.
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Elimination of human leukemia cells in NOD/SCID mice by WT1-TCR gene-transduced human T cells.
Shao-An Xue,Liquan Gao,Daniel P. Hart,Roopinder Gillmore,Waseem Qasim,Adrian J. Thrasher,Jane F. Apperley,Boris Engels,Wolfgang Uckert,Emma C. Morris,Hans J. Stauss +10 more
TL;DR: In this article, retroviral gene transfer was used to introduce a WT1-specific T-cell receptor (TCR) into T lymphocytes obtained from patients with leukemia and from healthy donors.
Journal ArticleDOI
Retroviral Vectors for High-Level Transgene Expression in T Lymphocytes
Boris Engels,Hakan Cam,Thomas Schüler,Stefano Indraccolo,Monika Gladow,Christopher Baum,Thomas Blankenstein,Wolfgang Uckert +7 more
TL;DR: MP71 vectors are useful tools for stable, high-level gene expression in T lymphocytes, for example, in the expression of T cell receptor genes.
Journal ArticleDOI
Tumour ischaemia by interferon-γ resembles physiological blood vessel regression
Thomas Kammertoens,Christian Friese,Christian Friese,Ainhoa Arina,Christian Idel,Dana Briesemeister,Dana Briesemeister,Michael Rothe,Michael Rothe,Andranik Ivanov,Anna Szymborska,Giannino Patone,Séverine Kunz,Daniel Sommermeyer,Boris Engels,Matthias Leisegang,Matthias Leisegang,Ana Textor,Ana Textor,Hans Joerg Fehling,Marcus Fruttiger,Michael Lohoff,Andreas Herrmann,Hua Yu,Ralph R. Weichselbaum,Wolfgang Uckert,Norbert Hubner,Norbert Hubner,Holger Gerhardt,Holger Gerhardt,Dieter Beule,Hans Schreiber,Hans Schreiber,Thomas Blankenstein,Thomas Blankenstein +34 more
TL;DR: Intravital microscopy revealed IFNγ-induced regression of the tumour vasculature, resulting in arrest of blood flow and subsequent collapse of tumours, similar to non-haemorrhagic necrosis in ischaemia and unlike haemor Rhotic necrosis induced by tumour necrosis factor.