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Bradley J. Hintze
Researcher at Duke University
Publications - 18
Citations - 5972
Bradley J. Hintze is an academic researcher from Duke University. The author has contributed to research in topics: Triple-stranded DNA & Base pair. The author has an hindex of 7, co-authored 18 publications receiving 2749 citations. Previous affiliations of Bradley J. Hintze include United States Department of Veterans Affairs & Durham University.
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Journal ArticleDOI
Model validation: local diagnosis, correction and when to quit.
Jane S. Richardson,Christopher J. Williams,Bradley J. Hintze,Vincent B. Chen,Michael G. Prisant,Lizbeth L. Videau,David S. Richardson +6 more
TL;DR: An overview is provided of current crystallographic model validation of proteins and RNA, both foundations and criteria, at all resolution ranges, together with advice on how to correct specific types of problems and when you should not try so hard that you are overfitting.
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Comparison of Annotation Services for Next-Generation Sequencing in a Large-Scale Precision Oncology Program
Evangelia Katsoulakis,Jill E. Duffy,Bradley J. Hintze,Neil L. Spector,Neil L. Spector,Michael J. Kelley,Michael J. Kelley +6 more
TL;DR: There is substantial variability in pathogenicity assessment of NGS variants in solid tumors by annotation services, and there was only moderate agreement in level 1 therapeutic actionability recommendations between WfG and OncoKB.
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Genomic Analysis of Metastatic Solid Tumors in Veterans: Findings From the VHA National Precision Oncology Program.
Pradeep J. Poonnen,Pradeep J. Poonnen,Jill E. Duffy,Bradley J. Hintze,Bradley J. Hintze,Maulik Shukla,Thomas Brettin,Neal Conrad,Hyunseung Yoo,Christopher M Guertin,Jane A. Looney,Vishal Vashistha,Vishal Vashistha,Michael J. Kelley,Michael J. Kelley,Michael J. Kelley,Neil L. Spector,Neil L. Spector,Neil L. Spector +18 more
TL;DR: Clinical implementation of precision oncology is feasible across the VHA health care system, including rural sites, and Mutations in genes associated with a neuroendocrine prostate cancer phenotype were expressed at increased frequency among veterans than in the general population.
Journal ArticleDOI
Mismodeled purines: implicit alternates and hidden Hoogsteens
TL;DR: The primary conclusions are that such mistakes are infrequent, the bias towards fitting anti purines is very slight, and the occurrence rate of Hoogsteen base pairs in DNA crystal structures remains unchanged from earlier estimates at ∼0.3%.
Journal ArticleDOI
Barriers to Prescribing Targeted Therapies for Patients With NSCLC With Highly Actionable Gene Variants in the Veterans Affairs National Precision Oncology Program
Vishal Vashistha,Jenna L Armstrong,Jenna L Armstrong,David Winski,Pradeep J. Poonnen,Bradley J. Hintze,Meghan Price,Meghan Price,Jane L. Snowdon,Dilhan Weeraratne,David Brotman,Gretchen Purcell Jackson,Gretchen Purcell Jackson,Michael J. Kelley +13 more
TL;DR: In this article, next-generation sequencing (NGS) gene panels are frequently completed for patients with advanced non-small-cell lung cancer (NSCLC) and patients with highly actionable gene variants have impro...