B
Brenda Bradley
Researcher at University of Colorado Denver
Publications - 18
Citations - 1808
Brenda Bradley is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: NOD mice & Islet. The author has an hindex of 16, co-authored 18 publications receiving 1595 citations. Previous affiliations of Brenda Bradley include Anschutz Medical Campus & University of Montana.
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Journal ArticleDOI
Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion
Thomas Delong,Timothy A. Wiles,Rocky L. Baker,Brenda Bradley,Gene Barbour,Richard Reisdorph,Michael Armstrong,Roger Powell,Nichole Reisdorph,Nitesh Kumar,Colleen M. Elso,Megan E DeNicola,Rita Bottino,Alvin C. Powers,David M. Harlan,Sally C. Kent,Stuart I. Mannering,Kathryn Haskins +17 more
TL;DR: It is found that diabetes-inducing CD4 T cell clones isolated from nonobese diabetic mice recognize epitopes formed by covalent cross-linking of proinsulin peptides to other peptides present in β cell secretory granules, which may explain how immune tolerance is broken in T1D.
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Chromogranin A is an autoantigen in type 1 diabetes
Brian D. Stadinski,Thomas Delong,Nichole Reisdorph,Richard Reisdorph,Roger Powell,Michael Armstrong,Jon D. Piganelli,Jon D. Piganelli,Gene Barbour,Brenda Bradley,Frances Crawford,Frances Crawford,Philippa Marrack,Philippa Marrack,Sushil K. Mahata,John W. Kappler,John W. Kappler,Kathryn Haskins +17 more
TL;DR: The peptide WE14 from chromogranin A (ChgA) is identified as the antigen for highly diabetogenic CD4+ T cell clones in the nonobese diabetic (NOD) mouse model of type 1 diabetes and supports the idea that autoreactive T cells respond to unusually presented self peptides.
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Oxidative Stress in Type 1 Diabetes
Kathryn Haskins,Brenda Bradley,Katherine Powers,Valerie Fadok,Sonia C. Flores,Xiaofeng Ling,Subbiah Pugazhenthi,Jane E.B. Reusch,Jennifer A. Kench +8 more
TL;DR: It is demonstrated that treatment of prediabetic NOD mice for 2 weeks with a metalloporphyrin superoxide dismutase (SOD) mimetic results in marked reduction of oxidative stress in islets and vascular tissue and a reversal of macrophage defects.
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T-lymphocyte clone specific for pancreatic islet antigen.
TL;DR: It is suggested that the islet-specific T-lymphocytes mediate islet destruction in a tissue-specific manner in an in vivo transplantation system in which islet grafts were made in the presence or absence of the BDC-2.5.
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PEG-based hydrogels as an in vitro encapsulation platform for testing controlled β-cell microenvironments
TL;DR: The compatibility of the PEG encapsulation system with freshly isolated islets was confirmed and encapsulated MIN6 beta-cells transplanted into diabetic mice returned blood glucose levels to normal levels, indicating in vivo function.