N
Nichole Reisdorph
Researcher at University of Montana
Publications - 140
Citations - 4963
Nichole Reisdorph is an academic researcher from University of Montana. The author has contributed to research in topics: Medicine & Metabolome. The author has an hindex of 33, co-authored 128 publications receiving 3765 citations. Previous affiliations of Nichole Reisdorph include Scripps Research Institute & University of Colorado Denver.
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Journal ArticleDOI
Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion
Thomas Delong,Timothy A. Wiles,Rocky L. Baker,Brenda Bradley,Gene Barbour,Richard Reisdorph,Michael Armstrong,Roger Powell,Nichole Reisdorph,Nitesh Kumar,Colleen M. Elso,Megan E DeNicola,Rita Bottino,Alvin C. Powers,David M. Harlan,Sally C. Kent,Stuart I. Mannering,Kathryn Haskins +17 more
TL;DR: It is found that diabetes-inducing CD4 T cell clones isolated from nonobese diabetic mice recognize epitopes formed by covalent cross-linking of proinsulin peptides to other peptides present in β cell secretory granules, which may explain how immune tolerance is broken in T1D.
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MPYS, a Novel Membrane Tetraspanner, Is Associated with Major Histocompatibility Complex Class II and Mediates Transduction of Apoptotic Signals
TL;DR: A novel plasma membrane tetraspanner (MPYS) that is associated with MHC-II and mediates its transduction of death signals, which requires MPYS-dependent activation of the extracellular signal-regulated kinase signaling pathway.
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Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults
Christopher R. Martens,Blair A Denman,Melissa R. Mazzo,Michael Armstrong,Nichole Reisdorph,Matthew B. McQueen,Michel Chonchol,Douglas R. Seals +7 more
TL;DR: Results of a double-blind, randomized crossover trial are presented to show that nicotinamide riboside effectively elevates NAD+ levels in humans, appears to be well tolerated, and may have potential to improve cardiovascular parameters.
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Chromogranin A is an autoantigen in type 1 diabetes
Brian D. Stadinski,Thomas Delong,Nichole Reisdorph,Richard Reisdorph,Roger Powell,Michael Armstrong,Jon D. Piganelli,Jon D. Piganelli,Gene Barbour,Brenda Bradley,Frances Crawford,Frances Crawford,Philippa Marrack,Philippa Marrack,Sushil K. Mahata,John W. Kappler,John W. Kappler,Kathryn Haskins +17 more
TL;DR: The peptide WE14 from chromogranin A (ChgA) is identified as the antigen for highly diabetogenic CD4+ T cell clones in the nonobese diabetic (NOD) mouse model of type 1 diabetes and supports the idea that autoreactive T cells respond to unusually presented self peptides.
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Analysis of 25 underivatized amino acids in human plasma using ion‐pairing reversed‐phase liquid chromatography/time‐of‐flight mass spectrometry
TL;DR: The LC/MS technique described in this study relies on mass accuracy and is suitable for the quantitation of free amino acids in plasma and was found to be within physiological levels for all amino acids analyzed.