Brenda D. Spangler

TL;DR: The recent elucidation of the three-dimensional structure of the heat-labile enterotoxin has provided an opportunity to examine and compare the correlations between structure and function of the two toxins, which may improve understanding of the disease process itself and illuminate the role of the toxin in studies of signal transduction and G-protein function.

TL;DR: The three-dimensional structure of choleragen, along with those of related toxins from Shigella dysenteria and Bordetella pertussis, offer a first step towards the rational design of new vaccines and anti-microbial agents.

TL;DR: While neither device matches the sensitivity of enzyme-linked immunosorbant assay (ELISA) for detection of picograms amounts of analyte, measurements can be obtained directly, in minutes, rather than the hours required to visualize results of an ELISA.

TL;DR: Antipeptide mAb raised against synthetic peptides derived from cholera toxin, myohemerythrin, and sickle hemoglobin were analyzed and none of the antibodies recognized the Ag in its true native form, failing to bind when tested in several solution-phase assay systems, including size exclusion HPLC.

TL;DR: In this paper, the 2-photon absorption (2PA) spectra in a broad class of organic dye molecules, such as substituted diphenylaminostilbenes, push−pull porphyrins, and carbazol-substituted stil benes, were studied and the 2PA cross section in the lowest energy dipole-allowed transition was predicted with better than 50% absolute accuracy based solely on the molecular parameters obtained from linear spectroscopic measurements.