The three-dimensional crystal structure of cholera toxin.
Rong-Guang Zhang,David Scott,Mary L. Westbrook,Sharon Nance,Brenda D. Spangler,G. Graham Shipley,Edwin M. Westbrook +6 more
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TLDR
The three-dimensional structure of choleragen, along with those of related toxins from Shigella dysenteria and Bordetella pertussis, offer a first step towards the rational design of new vaccines and anti-microbial agents.About:
This article is published in Journal of Molecular Biology.The article was published on 1995-08-25 and is currently open access. It has received 331 citations till now. The article focuses on the topics: Choleragenoid & Cholera toxin.read more
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HOLE: a program for the analysis of the pore dimensions of ion channel structural models.
TL;DR: A method (HOLE) that allows the analysis of the dimensions of the pore running through a structural model of an ion channel is presented and can be used to predict the conductance of channels using a simple empirically corrected ohmic model.
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Structural symmetry and protein function
TL;DR: Examples have been found for all of the crystallographic point groups, demonstrating that functional need can drive the evolution of any symmetry.
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CD95 signaling via ceramide-rich membrane rafts.
Heike Grassmé,Andreas Jekle,Andrea Riehle,Heinz Schwarz,Juergen Berger,Konrad Sandhoff,Richard Kolesnick,Erich Gulbins +7 more
TL;DR: In vitro and in vivo, extracellularly orientated ceramide, released upon CD95-triggered translocation of ASM to the plasma membrane outer surface, enabled clustering of CD95 in sphingolipid-rich membrane rafts and apoptosis induction.
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Protein disulfide isomerase acts as a redox-dependent chaperone to unfold cholera toxin.
TL;DR: It is shown that protein disulfide isomerase (PDI) in the ER lumen functions to disassemble and unfold the toxin once its A chain has been cleaved, indicating that PDI can act as a novel type of chaperone, whose binding and release of substrates is regulated by a redox, rather than an ATPase, cycle.
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Type II secretion and pathogenesis.
TL;DR: Proteins destined for the extracellular environment of gram-negative bacteria have to cross two membranes during their journey across the bacterial cell envelope, which involves translocation across.
References
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Book
Immunochemical and Molecular Genetic Analysis of Bacterial Pathogens
Peter Owen,Timothy J. Foster +1 more
TL;DR: This review discusses the construction of gene libraries in bacteriophage lambda vectors, strategies in bacterial vaccine development, and a simple method of bacterial characteristics and growth in vitro.