Mary L. Westbrook

TL;DR: The three-dimensional structure of choleragen, along with those of related toxins from Shigella dysenteria and Bordetella pertussis, offer a first step towards the rational design of new vaccines and anti-microbial agents.

TL;DR: The isomorphous structures of the hirugen (N-acetylhirudin 53′-64′ with sulfato-Tyr63′) and hirulog 1 (d -Phe-Pro-Arg-Pro-(Gly)4 desulfato-tyr 63′-hirugen) complexes of human α-thrombin have been determined and refined at 2.2Aresolution to crystallographic R-factors of 0.167 and 0.163, respectively as discussed by the authors.

TL;DR: The structure of the B subunits, and their pentameric arrangement, closely resembles that reported for the intact holotoxin, choleragen, the heat-labile enterotoxin from Escherichia coli, and for a Choleragenoid-GM1 pentasaccharide complex.

TL;DR: In this paper, a detector with a 114 mm aperture, based on a charge-coupled device (CCD), has been designed for X-ray diffraction studies in protein crystallography.

TL;DR: In this paper, a large area, multi-module, CCD-based detector without intensification stages is developed for X-ray diffraction applications, which consists of a fiberoptic taper with a phosphor deposited on the large end and a large format, scientific CCD bonded to the small end.