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Brendan T. Innes
Researcher at University of Toronto
Publications - 17
Citations - 1593
Brendan T. Innes is an academic researcher from University of Toronto. The author has contributed to research in topics: PIN1 & Prolyl isomerase. The author has an hindex of 9, co-authored 14 publications receiving 806 citations. Previous affiliations of Brendan T. Innes include University of Western Ontario.
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Journal ArticleDOI
Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations.
Sonya A. MacParland,Sonya A. MacParland,Jeff C. Liu,Xue Zhong Ma,Brendan T. Innes,Agata Bartczak,Blair K. Gage,Justin Manuel,Nicholas Khuu,Juan Echeverri,Ivan Linares,Rahul Gupta,Michael L Cheng,Lewis Y. Liu,Damra Camat,Sai W. Chung,Rebecca K. Seliga,Zigong Shao,Elizabeth Lee,Shinichiro Ogawa,Mina Ogawa,Michael D. Wilson,Jason E. Fish,Jason E. Fish,Markus Selzner,Anand Ghanekar,David R. Grant,Paul D. Greig,Gonzalo Sapisochin,Nazia Selzner,Neil Winegarden,Oyedele Adeyi,Oyedele Adeyi,Oyedele Adeyi,Gordon Keller,Gordon Keller,Gordon Keller,Gary D. Bader,Ian D. McGilvray +38 more
TL;DR: A map of the cellular landscape of the human liver using single-cell RNA sequencing is reported, and distinct populations of intrahepatic macrophages that may play specific roles in liver disease are identified.
Journal ArticleDOI
Single-cell transcriptomic profiling of the aging mouse brain.
Methodios Ximerakis,Scott Lipnick,Brendan T. Innes,Sean Simmons,Xian Adiconis,Danielle Dionne,Brittany A Mayweather,Lan Nguyen,Zachary Niziolek,Ceren Ozek,Vincent L. Butty,Ruth Isserlin,Sean M. Buchanan,Stuart S. Levine,Aviv Regev,Gary D. Bader,Joshua Z. Levin,Lee L. Rubin,Lee L. Rubin +18 more
TL;DR: A single-cell transcriptomic atlas of the aging mouse brain reveals coordinated and cell-type-specific aging signatures across multiple cell populations, and highlights key molecular processes, including ribosome biogenesis, underlying brain aging.
Journal ArticleDOI
Developmental Emergence of Adult Neural Stem Cells as Revealed by Single-Cell Transcriptional Profiling
Scott A. Yuzwa,Michael J. Borrett,Brendan T. Innes,Anastassia Voronova,Troy Ketela,David R. Kaplan,Gary D. Bader,Freda D. Miller +7 more
TL;DR: A model wherein cortical RPs maintain a core transcriptional identity from embryogenesis through to adulthood and wherein the transition to a quiescent adult NSC occurs during late neurogenesis is supported.
Journal ArticleDOI
Tutorial: guidelines for annotating single-cell transcriptomic maps using automated and manual methods.
Zoe A Clarke,Tallulah S Andrews,Tallulah S Andrews,Jawairia Atif,Jawairia Atif,Delaram Pouyabahar,Brendan T. Innes,Sonya A. MacParland,Sonya A. MacParland,Gary D. Bader +9 more
TL;DR: In this paper, the authors provide guidelines for interpreting single-cell transcriptomic maps to identify cell types, states and other biologically relevant patterns with the objective of creating an annotated map of cells.
Journal ArticleDOI
Generation of Functional Liver Sinusoidal Endothelial Cells from Human Pluripotent Stem-Cell-Derived Venous Angioblasts.
Blair K. Gage,Jeff C. Liu,Brendan T. Innes,Sonya A. MacParland,Sonya A. MacParland,Ian D. McGilvray,Gary D. Bader,Gordon Keller,Gordon Keller +8 more
TL;DR: Humanization of the murine liver with hPSC-derived LSECs provides a tractable system for studying the biology of this key liver cell type.