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Brent E. Palmer
Researcher at University of Colorado Denver
Publications - 123
Citations - 6896
Brent E. Palmer is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 40, co-authored 115 publications receiving 6018 citations. Previous affiliations of Brent E. Palmer include University of Colorado Boulder & Denver Health Medical Center.
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Journal ArticleDOI
IL-37 is a fundamental inhibitor of innate immunity.
Marcel F. Nold,Claudia A. Nold-Petry,Claudia A. Nold-Petry,Jarod A. Zepp,Brent E. Palmer,Philip Bufler,Charles A. Dinarello +6 more
TL;DR: IL-37 emerged as a natural suppressor of innate inflammatory and immune responses and protected from lipopolysaccharide-induced shock, and transgenic mice showed less cytokine suppression when endogenous Smad3 was depleted.
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Negative Immune Regulator Tim-3 Is Overexpressed on T Cells in Hepatitis C Virus Infection and Its Blockade Rescues Dysfunctional CD4+ and CD8+ T Cells
Lucy Golden-Mason,Brent E. Palmer,Nasim Kassam,Lisa Townshend-Bulson,Stephen Livingston,Brian J. McMahon,Brian J. McMahon,Nicole Castelblanco,Vijay K. Kuchroo,David R. Gretch,Hugo R. Rosen +10 more
TL;DR: For the first time, it is found that Tim-3 expression is increased on CD4+ and CD8+ T cells in chronic hepatitis C virus (HCV) infection and the ability to enhance T-cell proliferation and gamma interferon production in response to HCV-specific antigens by blocking the Tim- 3-Tim-3 ligand interaction is demonstrated.
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Upregulation of PD-1 Expression on Circulating and Intrahepatic Hepatitis C Virus-Specific CD8+ T Cells Associated with Reversible Immune Dysfunction
Lucy Golden-Mason,Brent E. Palmer,Jared Klarquist,John A. Mengshol,Nicole Castelblanco,Hugo R. Rosen +5 more
TL;DR: It is demonstrated that the inhibitory molecule programmed death-1 (PD-1) is significantly upregulated on total and HCV-specific CD8+ cytotoxic T lymphocytes in the peripheral blood and livers of patients with chronic infection compared to subjects with spontaneous HCV resolution, patients with nonviral liver disease, and normal controls.
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Alterations in the Gut Microbiota Associated with HIV-1 Infection
Catherine A. Lozupone,Marcella Li,Thomas B. Campbell,Sonia C. Flores,Derek J. Linderman,Matthew J. Gebert,Rob Knight,Rob Knight,Andrew P. Fontenot,Brent E. Palmer +9 more
TL;DR: Evaluating innate and adaptive immune responses to lysates from bacteria that differ with HIV explores the functional drivers of these compositional differences and identifies Prevotella-rich community composition most similar to healthy individuals in agrarian cultures of Malawi and Venezuela.
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Programmed Death 1 Expression on HIV-Specific CD4+ T Cells Is Driven by Viral Replication and Associated with T Cell Dysfunction
Michelle D'Souza,Andrew P. Fontenot,Doug G. Mack,Catherine A. Lozupone,Stephanie M. Dillon,Amie L. Meditz,Cara C. Wilson,Elizabeth Connick,Brent E. Palmer +8 more
TL;DR: PD-1 expression on HIV- specific CD4+ T cells is driven by persistent HIV replication, providing a potential target for enhancing the functional capacity of HIV-specific CD4- T cells.