S
Stephanie M. Dillon
Researcher at Anschutz Medical Campus
Publications - 51
Citations - 3474
Stephanie M. Dillon is an academic researcher from Anschutz Medical Campus. The author has contributed to research in topics: T cell & Cytokine. The author has an hindex of 24, co-authored 49 publications receiving 3068 citations. Previous affiliations of Stephanie M. Dillon include University of Colorado Denver & University of Otago.
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Journal ArticleDOI
Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance
Stephanie M. Dillon,Sudhanshu Agrawal,Kaustuv Banerjee,John J. Letterio,Timothy L. Denning,Kyra Oswald-Richter,Deborah J. Kasprowicz,Kathryn L. Kellar,Jeff Pare,Thomas E. Van Dyke,Steven F. Ziegler,Derya Unutmaz,Bali Pulendran +12 more
TL;DR: It is shown that zymosan, a stimulus for TLR2 and dectin-1, regulates cytokine secretion in DCs and macrophages to induce immunological tolerance and suggest several targets for pharmacological modulation of immune responses in various clinical settings.
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A Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-Fos in dendritic cells.
Stephanie M. Dillon,Anshu Agrawal,Thomas E. Van Dyke,Gary E. Landreth,Laurie K. McCauley,Amy J. Koh,Charles R. Maliszewski,Shizuo Akira,Bali Pulendran +8 more
TL;DR: It is demonstrated that different Toll-like receptor (TLR) ligands induce distinct dendritic cell activation and immune responses in vivo, and differentially bias Th responses in vitro and in vivo.
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An altered intestinal mucosal microbiome in HIV-1 infection is associated with mucosal and systemic immune activation and endotoxemia
Stephanie M. Dillon,Eric J. Lee,Cassandra V. Kotter,Gregory L. Austin,Z Dong,Daniel K. Hecht,Sara Gianella,Basile Siewe,Davey M. Smith,Alan L. Landay,Charles E. Robertson,Daniel N. Frank,Cara C. Wilson +12 more
TL;DR: Observations suggest that an important relationship exists between altered mucosal bacterial communities and intestinal inflammation during chronic HIV-1 infection, as well as with levels of systemic T-cell activation, inflammation, and microbial translocation.
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Programmed Death 1 Expression on HIV-Specific CD4+ T Cells Is Driven by Viral Replication and Associated with T Cell Dysfunction
Michelle D'Souza,Andrew P. Fontenot,Doug G. Mack,Catherine A. Lozupone,Stephanie M. Dillon,Amie L. Meditz,Cara C. Wilson,Elizabeth Connick,Brent E. Palmer +8 more
TL;DR: PD-1 expression on HIV- specific CD4+ T cells is driven by persistent HIV replication, providing a potential target for enhancing the functional capacity of HIV-specific CD4- T cells.
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Gut dendritic cell activation links an altered colonic microbiome to mucosal and systemic T-cell activation in untreated HIV-1 infection
Stephanie M. Dillon,Eric J. Lee,Cassandra V. Kotter,Gregory L. Austin,Sara Gianella,Basile Siewe,Davey M. Smith,Alan L. Landay,McManus Mc,Charles E. Robertson,Charles E. Robertson,Daniel N. Frank,Daniel N. Frank,McCarter,Cara C. Wilson +14 more
TL;DR: Colonic mDCs in HIV-1-infected subjects had increased CD40 but decreased CD83 expression, and CD40 expression on CD1c+ m DCs positively correlated with mucosal HIV- 1 viral load, with mucosa and systemic cytokine production, and with frequencies of activated colon and blood T cells.