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Derek J. Linderman
Researcher at University of Colorado Denver
Publications - 16
Citations - 2128
Derek J. Linderman is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Integrated care & Phagocytosis. The author has an hindex of 11, co-authored 16 publications receiving 1921 citations. Previous affiliations of Derek J. Linderman include University of Colorado Hospital.
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Journal ArticleDOI
Mechanisms of Resistance to Crizotinib in Patients with ALK Gene Rearranged Non-Small Cell Lung Cancer
Robert C. Doebele,Amanda B. Pilling,Dara L. Aisner,Tatiana G. Kutateladze,Anh T. Le,Andrew Weickhardt,Kimi L. Kondo,Derek J. Linderman,Lynn E. Heasley,Wilbur A. Franklin,Marileila Varella-Garcia,D. Ross Camidge +11 more
TL;DR: Crizotinib resistance in ALK+ NSCLC occurs through somatic kinase domain mutations, ALK gene fusion CNG, and emergence of separate oncogenic drivers.
Journal ArticleDOI
Alterations in the Gut Microbiota Associated with HIV-1 Infection
Catherine A. Lozupone,Marcella Li,Thomas B. Campbell,Sonia C. Flores,Derek J. Linderman,Matthew J. Gebert,Rob Knight,Rob Knight,Andrew P. Fontenot,Brent E. Palmer +9 more
TL;DR: Evaluating innate and adaptive immune responses to lysates from bacteria that differ with HIV explores the functional drivers of these compositional differences and identifies Prevotella-rich community composition most similar to healthy individuals in agrarian cultures of Malawi and Venezuela.
Journal ArticleDOI
Surfactant Proteins A and D Suppress Alveolar Macrophage Phagocytosis via Interaction with SIRPα
William J. Janssen,Kathleen A. McPhillips,Matthew Dickinson,Derek J. Linderman,Konosuke Morimoto,Yi Qun Xiao,Kelly M. Oldham,R. William Vandivier,Peter M. Henson,Shyra J. Gardai +9 more
TL;DR: SP-A and SP-D tonically inhibit alveolar macrophage phagocytosis by binding SIRP alpha, which is essential for the resolution of acute pulmonary inflammation.
Journal ArticleDOI
Widespread colonization of the lung by Tropheryma whipplei in HIV infection.
Catherine A. Lozupone,Adela Cota-Gomez,Brent E. Palmer,Derek J. Linderman,Emily S. Charlson,Erica Sodergren,Makedonka Mitreva,Sahar Abubucker,John Martin,Guohui Yao,Thomas B. Campbell,Sonia C. Flores,Gail Ackerman,Jesse Stombaugh,Luke K. Ursell,James M. Beck,James M. Beck,Jeffrey L. Curtis,Vincent B. Young,Susan V. Lynch,Laurence Huang,George M. Weinstock,Kenneth S. Knox,Homer L. Twigg,Alison Morris,Elodie Ghedin,Frederic D. Bushman,Ronald G. Collman,Rob Knight,Rob Knight,Andrew P. Fontenot +30 more
TL;DR: Asymptomatic subjects with HIV infection have unexpected colonization of the lung by T. whipplei, which is reduced by effective antiretroviral therapy and merits further study for a potential pathogenic role in chronic pulmonary complications of HIV infection.
Journal ArticleDOI
Cigarette Smoke Impairs Clearance of Apoptotic Cells through Oxidant-dependent Activation of RhoA
Tiffany R. Richens,Derek J. Linderman,Sarah A. Horstmann,Cherie Lambert,Yi-Qun Xiao,Robert L. Keith,Darren M. Boe,Konosuke Morimoto,Russell P. Bowler,Brian J. Day,William J. Janssen,Peter M. Henson,R. William Vandivier +12 more
TL;DR: The hypothesis that impaired efferocytosis may contribute to the pathogenesis of COPD is advanced and the therapeutic potential of drugs targeting the RhoA-Rho kinase pathway is suggested.