B
Brian Dean
Researcher at Florey Institute of Neuroscience and Mental Health
Publications - 308
Citations - 12705
Brian Dean is an academic researcher from Florey Institute of Neuroscience and Mental Health. The author has contributed to research in topics: Schizophrenia & Psychosis. The author has an hindex of 56, co-authored 289 publications receiving 11493 citations. Previous affiliations of Brian Dean include Centre for Mental Health & University of Papua New Guinea.
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Journal ArticleDOI
Pathways underlying neuroprogression in bipolar disorder : focus on inflammation, oxidative stress and neurotrophic factors
Michael Berk,Flávio Kapczinski,Ana Cristina Andreazza,Ana Cristina Andreazza,Olivia M Dean,Olivia M Dean,Francesco Giorlando,Francesco Giorlando,Michael Maes,Murat Yücel,Clarissa Severino Gama,Seetal Dodd,Seetal Dodd,Brian Dean,Brian Dean,Pedro Vieira da Silva Magalhães,Pedro Vieira da Silva Magalhães,G. Paul Amminger,Patrick D. McGorry,Gin S Malhi +19 more
TL;DR: Emerging data shows that these biomarkers may differ between early and late stages of BD in parallel with stage-related structural and neurocognitive alterations, which facilitates identification of rational therapeutic targets, and the development of novel treatment classes.
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Studies on [3H]CP-55940 binding in the human central nervous system: regional specific changes in density of cannabinoid-1 receptors associated with schizophrenia and cannabis use.
TL;DR: Data indicate that there are changes in cannabinoid-1 receptors in the dorsolateral prefrontal cortex that may prove to be associated with the pathology of schizophrenia, and changes in the density of cannabinoid- 1 receptors may occur in the caudate-putamen in response to cannabis ingestion.
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Ionotropic glutamate receptors and expression of N-methyl-D-aspartate receptor subunits in subregions of human hippocampus: effects of schizophrenia.
TL;DR: Because the NR1 subunit of theNMDA receptor is critical to full receptor activity, a reduction of NR1 in hippocampus in schizophrenia suggests a functional impairment in glutamatergic transmission at the NMDA receptor, resulting in reduced glutamatership transmission within and possibly efferent from the hippocampus in schizophrenic patients.
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Individual differences in allocation of funds in the dictator game associated with length of the arginine vasopressin 1a receptor RS3 promoter region and correlation between RS3 length and hippocampal mRNA
A Knafo,S Israel,A Darvasi,R Bachner-Melman,Florina Uzefovsky,L Cohen,E Feldman,E Lerer,E. Laiba,Y. Raz,L Nemanov,I Gritsenko,C Dina,Galila Agam,Brian Dean,G Bornstein,Richard P. Ebstein +16 more
TL;DR: This is the first investigation showing that a common human polymorphism, with antecedents in lower mammals, contributes to decision making in an economic game.
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Towards a muscarinic hypothesis of schizophrenia
TL;DR: Evidence is focused on evidence that supports the hypothesis that the muscarinic system is involved in the pathogenesis of schizophrenia and thatmuscarinic receptors may represent promising novel targets for the treatment of this disorder.