C
Clarissa Severino Gama
Researcher at Universidade Federal do Rio Grande do Sul
Publications - 147
Citations - 6594
Clarissa Severino Gama is an academic researcher from Universidade Federal do Rio Grande do Sul. The author has contributed to research in topics: Bipolar disorder & Schizophrenia. The author has an hindex of 37, co-authored 136 publications receiving 5861 citations. Previous affiliations of Clarissa Severino Gama include Barwon Health & National Council for Scientific and Technological Development.
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Journal ArticleDOI
Pathways underlying neuroprogression in bipolar disorder : focus on inflammation, oxidative stress and neurotrophic factors
Michael Berk,Flávio Kapczinski,Ana Cristina Andreazza,Ana Cristina Andreazza,Olivia M Dean,Olivia M Dean,Francesco Giorlando,Francesco Giorlando,Michael Maes,Murat Yücel,Clarissa Severino Gama,Seetal Dodd,Seetal Dodd,Brian Dean,Brian Dean,Pedro Vieira da Silva Magalhães,Pedro Vieira da Silva Magalhães,G. Paul Amminger,Patrick D. McGorry,Gin S Malhi +19 more
TL;DR: Emerging data shows that these biomarkers may differ between early and late stages of BD in parallel with stage-related structural and neurocognitive alterations, which facilitates identification of rational therapeutic targets, and the development of novel treatment classes.
Journal ArticleDOI
Brain-derived neurotrophic factor as a state-marker of mood episodes in bipolar disorders: A systematic review and meta-regression analysis
Brisa Simoes Fernandes,Clarissa Severino Gama,Keila Maria Mendes Ceresér,Lakshmi N. Yatham,Gabriel Rodrigo Fries,Gabriela D. Colpo,David Freitas de Lucena,Maurício Kunz,Fabiano Alves Gomes,Flávio Kapczinski +9 more
TL;DR: BDNF levels are consistently reduced during manic and depressive episodes and recover after treatment for acute mania, and data suggest that peripheral BDNF could be used as a biomarker of mood states and disease progression for BD.
Journal ArticleDOI
Peripheral biomarkers and illness activity in bipolar disorder.
Flávio Kapczinski,Felipe Dal-Pizzol,Antônio Lúcio Teixeira,Pedro Vieira da Silva Magalhães,Márcia Kauer-Sant'Anna,Fábio Klamt,José Cláudio Fonseca Moreira,Mateus Augusto de Bittencourt Pasquali,Gabriel Rodrigo Fries,João Quevedo,Clarissa Severino Gama,Robert M. Post +11 more
TL;DR: An en bloc assessment of a set of previously described biomarkers in different mood states as well as in healthy subjects, finding several of the markers discriminated between the bipolar and control groups, especially when patients were in acute episodes.
Journal ArticleDOI
Elevated serum superoxide dismutase and thiobarbituric acid reactive substances in different phases of bipolar disorder and in schizophrenia
Maurício Kunz,Clarissa Severino Gama,Ana Cristina Andreazza,Mirian Salvador,Keila Mendes Ceresér,Fabiano Alves Gomes,Paulo Belmonte-de-Abreu,Michael Berk,Michael Berk,Flávio Kapczinski +9 more
TL;DR: The findings show increased SOD activity in SZ, as well as in depressed and manic bipolar patients, but not in euthymic BD subjects, which suggests a dysregulation in oxidative defenses in both disorders.
Journal ArticleDOI
Serum levels of IL-6, IL-10 and TNF-α in patients with bipolar disorder and schizophrenia: differences in pro- and anti-inflammatory balance
Maurício Kunz,Keila Maria Mendes Ceresér,Pedro Domingues Goi,Gabriel Rodrigo Fries,Antônio Lúcio Teixeira,Brisa Simoes Fernandes,Paulo Belmonte-de-Abreu,Márcia Kauer-Sant'Anna,Flávio Kapczinski,Clarissa Severino Gama +9 more
TL;DR: These findings evidence a chronic immune activation in schizophrenia, and increased anti-inflammatory factor IL-10 in bipolar disorder and schizophrenia suggests different patterns of inflammatory balance between these two disorders.